犬门静脉无水酒精栓塞诱导肝叶代偿性增生的实验研究  

Experimental Portal Vein Embolization by Absolute Ethanol forObservation of Compensatory Hypertrophy of the Remnant Liver in Dog

作　　者：黄兢姚[1] 杨维竹[1] 江娜[1] 李建军[1] 唐建云[1] 吴定荣[1] 吴金庸[1] 

机构地区：[1]福建医科大学附属协和医院介入科,福州350001

出　　处：《福建医科大学学报》2004年第4期395-398,共4页Journal of Fujian Medical University

基　　金：福建省卫生厅青年科研基金资助项目 ( 2 0 0 4 1 5 )

摘　　要：目的　研究无水酒精犬门静脉分支栓塞诱导肝叶代偿增生的有效性与安全性。　方法　成年杂种犬12只 ,选择性门静脉左支无水酒精栓塞。通过CT、DSA等检查观察栓塞效果 ,并评估安全性 ;观察栓塞前后犬非栓塞侧的体积变化 ,对结果进行方差分析。　结果　栓塞术后 6周 ,10只存活犬的非栓塞侧肝体积较栓塞前增大33 1% ,观察 8周未发现门静脉再通、门静脉高压及肝功能损害等现象。　结论　门静脉分支的栓塞可以引起肝叶的萎缩 ,又可促使非栓塞肝叶的代偿性增生 ,门静脉分支栓塞是安全有效的 ,用无水酒精可以取得较好的栓塞效果。Objective To evaluate the usefulness and safety of portal vein branch embolization inducing compensatory hypertrophy of the remnant liver by absolute ethanol. Methods 12 adult dogs were enrolled, left branch portal vein embolization(PVE) was performed in each dog respectively. The results and security of absolute ethanol embolization examined by CT and DSA. Results Two dogs died with respiratory arrest and acute hepatic failure, embolization was complete in the remaining ten dogs. The volume of ten alive dogs non-embolized liver had increased 33.1% after six weeks. ALT were only mild changes. Recanalization of embolized vessels, hepatic dysfunction and portal hypertension were not found during 8 weeks observation. Conclusion Portal vein branch embolization can induce atrophy of the embolized lobes and compensatory hypertrophy of the remnant liver. The portal vein branch embolization is safe and effective. Using of absolute ethanol bring satisfactory result.

关 键 词：门静脉 肝 栓塞 治疗性 狗 

分 类 号：R735.7[医药卫生—肿瘤]