HMG-CoA还原酶抑制剂的合成(下)  

Synthesis of Hypolipidemic HMG-CoA Reductase Inhibitors

作　　者：蔡正艳[1] 宁奇[1] 周伟澄[1] 

机构地区：[1]上海医药工业研究院,上海200437

出　　处：《中国医药工业杂志》2004年第11期687-691,共5页Chinese Journal of Pharmaceuticals

摘　　要：Several synthetic methods for hypolipidemic HMG-CoA reductase inhibitors were reviewed, including thepreparation of the side chains with the suitable groups such as aldehydo, acetylenyl, sulfonyl, phosphono or amino as well as thecondensation of these chains with the heteroaromatic compounds by Wittig-Hornor or Julia-Kocienski Olefination reaction.Several synthetic methods for hypolipidemic HMG-CoA reductase inhibitors were reviewed, including thepreparation of the side chains with the suitable groups such as aldehydo, acetylenyl, sulfonyl, phosphono or amino as well as thecondensation of these chains with the heteroaromatic compounds by Wittig-Hornor or Julia-Kocienski Olefination reaction.

关 键 词：HMG-COA还原酶抑制剂 药物 WITTIG反应 合成 侧链 缩合 常用方法 甲基 芳香化合物 

分 类 号：R972[医药卫生—药品]