SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currentsin cultured hippocampal neurons in rats  

作　　者：LeiWEN ShengYANG Hai-faQIAO Wen-xiaZHOU Yong-xiangZHANG Pei-tangHUANG 

机构地区：[1]BeijingInstituteofPharmacologyandToxicologyBeijing100850,China [2]BeijingInstituteofBiotechnology,Beijing100071,China

出　　处：《Acta Pharmacologica Sinica》2004年第11期1556-1556,共1页中国药理学报（英文版）

摘　　要：AIM: To define the ion channel target of SO-3, a new O-super-family conopeptide derived from Conus striatus. METHODS: Pharmacologically isolated whole-cell currents were recorded by patch-clamp technique in cultured hippocampal neurons.RESULTS: SO-3 had no effect on voltage-sensitive sodium currents, delayed rectifier potassium currents and transient outward potassium currents even at the dose of 100 μmol·L^-1.

关 键 词：SO-3 O-超科 锥突带状 选择性 抑制作用 N-型 钙元素 海马神经 老鼠 神经细胞 

分 类 号：R741[医药卫生—神经病学与精神病学]