影响上皮性卵巢癌远期疗效的因素分析  

Analysis of Long-term Prognostic Factors of Epithelial Ovarian Cancer

作　　者：李孟达[1] 李玉洁[1] 黄永文[1] 黄鹤[1] 

机构地区：[1]中山大学肿瘤肿瘤防治中心妇科,广东广州510060

出　　处：《癌症》2004年第11期1306-1310,共5页Chinese Journal of Cancer

摘　　要：背景与目的:由于多数卵巢癌患者就诊时已属晚期,且易复发,故卵巢癌在治疗上较困难。本研究旨在探讨影响上皮性卵巢癌远期疗效的因素,以便指导临床实践。方法:回顾性分析1986年1月～2000年12月间我院治疗的691例上皮性卵巢癌,采用寿命表法计算生存率,并进行单因素分析,用Cox比例风险回归模型对影响生存率的有关因素进行多因素分析。结果:本组5年生存率为56.0%,10年生存率为44.6%。经Cox比例风险回归模型多因素分析,临床分期、残留癌灶大小、病理类型、组织学分级及术后化疗疗程数是影响预后的重要因素。结论:准确的临床分期和病理评价、满意的肿瘤细胞减灭术及术后有效、足量的化疗对上皮性卵巢癌预后影响均有重要意义。BACKGROUND &OBJECTIVE: Because most of patients with ovarian cancer are in advanced stage when initially noted, and are prone to relapse, ovarian cancer is a tough disease to treat. This study was to determine long term prognostic factors correlated with prolonged survival of epithelial ovarian cancer patients, give reference for clinical practice. METHODS: Records of 691 patients with epithelial ovarian cancer, admitted in our hospital from Jan. 1986 to Dec. 2000, were retrospectively analyzed. Survival rate was calculated by life table method, and relevant factors were evaluated by univariate analysis. The potential prognostic variables were studied by Cox regression model. RESULTS: The 5 year, and 10 year survival rates of all patients were 56.0%, and 44.6%. Cox regression model revealed that clinical stage, size of tumor residues, pathologic type, histological grade, and number of chemotherapy cycles after surgery emerged as independent prognostic factors. CONCLUSION: Accurate clinical staging and histopathologic assessment, satisfactory cytoreduction, and effective adequate chemotherapy may affect prognosis of ovarian cancer patients.

关 键 词：卵巢肿瘤 预后 多因素分析 

分 类 号：R737.31[医药卫生—肿瘤]