盐酸阿比朵尔抗流感病毒感染的药效学研究  

Study about pharmacodynamics ofarbidol hydrochloride on influenza virus infection

作　　者：靳玉琴[1] 孙非[1] 张淑芹[1] 刘志屹[1] 刘建伟[1] 闫琪[2] 

机构地区：[1]吉林大学再生医学科学研究所病毒研究室,吉林长春130021 [2]长春中医学院呼吸内科,吉林长春130021

出　　处：《中国药理学通报》2004年第10期1150-1152,共3页Chinese Pharmacological Bulletin

摘　　要：目的　探讨盐酸阿比朵尔的抗流感病毒作用。方法　建立体内、体外流感病毒模型 ,体外实验为应用一定浓度盐酸阿比朵尔作用于甲型流感病毒H1N1亚型病毒感染宿主细胞 ,通过观察CPE及采用MTT法测定细胞存活率 ;体内实验为应用盐酸阿比朵尔治疗流感病毒感染小鼠模型 ,计算肺指数的变化。结果　盐酸阿比朵尔在体内、体外均具有明显的抗流感病毒作用。结论　盐酸阿比朵尔是一种较好的抗流感病毒药物。Aim To study the antiviral function of Arbi do l hydrochloride on influenza virus.Methods In vitro and i n vivo models of influenza virus infection were established. In vitro,cer tain concentration of Arbidol hydrochloride was applied to host cells infected w ith with influenza virus,CPE and cell survival rate were determined by MTT me thod.In vivo,Arbidol hydrochloride was applied to mice infected with influe nza virus. The change of lung index was observed.Result Arbidol hydrochloride had significant effects on flu both in vivo and in vitro. Conclusion Arbidol hydrochloride was an effective medicine agai nst flu.

关 键 词：盐酸阿比朵尔 流感病毒 药效学 

分 类 号：R-332[医药卫生] R373.13