AgNORs形态定量在大肠癌病理及预后判定中的应用  

Study of AgNORs Morphometry in Colorrectal Carcinoma

作　　者：张京伟[1] 魏芸[2] 李春光[1] 兰海[1] 

机构地区：[1]武汉大学中南医院肿瘤科,武汉430071 [2]武汉大学医学院病毒学研究所,武汉430071

出　　处：《武汉大学学报（医学版）》2004年第6期705-707,共3页Medical Journal of Wuhan University

摘　　要：目的 :探讨AgNORs形态定量与大肠癌临床病理及预后的关系。 方法 :应用图像分析系统对 4 0例大肠腺癌、2 0例大肠腺瘤、2 0例正常粘膜细胞核中AgNORs颗粒进行形态定量分析。结果 :大肠腺癌AgNORs计数、颗粒面积、颗粒面积 /核面积均明显高于腺瘤及正常组 ,而形态系数则明显降低 (P <0 .0 5 ) ,各组间比较差异有显著性 ;同时生存 5年以上患者组AgNORs计数及面积均明显低于生存 5年以下者 ,P <0 .0 5。 结论 :AgNORs形态定量指标检测可作为大肠肿瘤良、恶性鉴别诊断分级及预后判断的一项定量指标。Objective: To explore the relationship between silver staining of nucleolar organizer regions(AgNORs) and pathologic factors in colorectal carcinoma and to evaluate its prognostic value. Methods: Automatic image analysis method was used to study AgNORs morphometry in 20 cases of normal mucosa, 20 cases of adenoma and 40 cases of adenocarcinoma of large bowel. Results: ① In adenocarcinoma, mean AgNORs praticles number, praticles area and praticles area/nucleu area was significantly more than those in adenoma and normal mucose. But the morph coefficient was significantly lower in adenocarcinoma. ② The patients survived longer than 5 years had a significant lower mean AgNORs partical number and area than those survived less than 5 years. Conclusion: The morphometric parameters of AgNORs can be act as useful indicators for early diagnosis and prognosis in colorectal tumor.

关 键 词：预后 大肠癌 核仁组成区相关蛋白 形态分析 

分 类 号：R735.34[医药卫生—肿瘤]