复方氟脲嘧啶的术前腹腔应用及其在胃癌组织中的分布  

Drug distribution in gastric cancer and adjacent tissues by preoperative intraperitoneal chemotherapy with Co-fluorouracil liposome

作　　者：李勇[1] 刘滨伟[1] 杜文力[2] 宋振川[1] 赵群[1] 范立侨[1] 杨进强[1] 李琦军[1] 王明霞[2] 焦志凯[1] 张志栋[1] 

机构地区：[1]河北医科大学第四医院外三科,石家庄050011 [2]河北医科大学第四医院药剂科,石家庄050011

出　　处：《中华肿瘤杂志》2004年第10期638-640,共3页Chinese Journal of Oncology

摘　　要：目的检测复方氟脲嘧啶(Co5Fu)术前腹腔灌注后在胃癌及其癌周组织中的分布,为开展Co5Fu术前腹腔化疗提供依据。方法胃癌96例,分为Co5Fu静脉滴注组(Co5Fuiv)、Co5Fu腹腔灌注组(Co5Fuip)、5Fu静脉组(5Fuiv)和5Fu腹腔灌注组(5Fuip)。各组分别于术前的2d、1d和60min用药。术中取材,应用高效液相色谱法测定各组织中氟脲嘧啶浓度。结果Co5Fuip组明显高于Co5Fuiv组和5Fuip组(P<0.05或P<0.01),而5Fuip组明显高于5Fuiv组(P<0.01)。各组药物分布浓度从高到低分别为Co5Fuip组为癌周淋巴结、癌组织、腹膜、胃黏膜、大网膜和小网膜,且前三种组织均分别明显高于后三种组织(P<0.01),癌周淋巴结明显高于其他组织(P<0.01),胃黏膜明显高于大网膜和小网膜(P<0.01);Co5Fuiv组为癌周淋巴结、癌组织、胃黏膜、腹膜、大网膜和小网膜,且前三种组织均分别明显高于后三种组织(P<0.01),癌组织明显高于其他组织(P<0.01);5Fuip组为腹膜、癌周淋巴结、癌组织、胃黏膜、大网膜和小网膜,前两种组织均分别明显高于其他组织(P<0.01)。结论Co5Fu具有对胃癌及癌周淋巴结的靶向性、缓释性和长效性。术前腹腔应用Co5Fu灌注,较静脉应用及腹腔应用5Fu在治疗胃癌中更具有优势。Objective To examine the distribution of fluorouracil in gastric cancer (CA), lymph node (LN), normal gastric mucosa (NG), peritoneum (PE), greater omentum (GO) and lesser omentum (LO) by preoperative intraperitoneal chemotherapy with Co fluorouracil liposome(Co 5 Fu), and offer an experimental basis for clinic practice. Methods Ninety six gastric cancer patients were divided into four groups: Co 5 Fu iv injection group(Co 5 Fu iv), Co 5 Fu intraperitoneal perfusion group (Co 5 Fu ip), 5 Fu iv injection group ( 5 Fu iv) and intraperitoneal perfusion group ( 5 Fu ip) given on day 2, day 1 and 60 minutes before operation. Fluorouracil concentration in all tissues collected during operation were examined by high performance liquid chromatography (HPLC). Results The fluorouracil concentration in the tissues in Co 5 Fu ip group was significantly higher than that in Co 5 Fu iv or 5 Fu ip group ( P <0.05 or P <0.01), and that in 5 Fu ip group was greatly higher than that at 5 Fu iv group ( P <0.01). In Co 5 Fu ip group, the concentration of drug in LN, CA, PE, NG, GO and LO decreased gradually with the former 3 tissues significantly higher than the latter 3 tissues( P <0.01), and adjacent lymph node was the highest. In Co 5 Fu iv group, the ranking was LN, CA, NG, PE, GO and LO with the former 3 tissues significantly higher than the latter 3 tissues( P <0.01) and showing tumor tissues higher than the other tissues( P <0.01). In 5 Fu ip group, the ranking was PE, LN, CA, NG, GO and LO with the former 2 tissues significantly higher than the latter tissues ( P <0.01). Conclusion Co 5 Fu possesses drug targeting, slow release and long effect in gastric cancer tissues and adjacent lymph nodes. Preoperative chemotherapy with Co 5 Fu ip is more advantageous than 5 Fu given iv or 5 Fu ip.

关 键 词：5-Fu 术前 大网膜 淋巴结 腹腔 氟脲嘧啶 胃癌 结论 长效性 取材 

分 类 号：R735.2[医药卫生—肿瘤]