多灶性脉络膜炎合并脉络膜新生血管的分析  

An Analysis of Multifocal Choroiditis with Choroidal Neovascularization

作　　者：黎蕾[1] 王文吉[1] 罗传淇[1] 张勇进[1] 高巧云[1] 沈颖[1] 

机构地区：[1]复旦大学附属眼耳鼻喉科医院,上海200031

出　　处：《中国临床医学》2004年第5期861-863,共3页Chinese Journal of Clinical Medicine

摘　　要：目的 :探讨多灶性脉络膜炎 (multifocalchoroiditis,MFC)合并脉络膜新生血管 (choroidalneovascularization ,CNV)的临床特点和治疗方法的选择。方法 :对 2 0 0 2～ 2 0 0 4年诊断的MFC合并CNV19例 2 0只眼的临床资料和荧光素眼底血管造影(fundusfluoresceinangiography ,FFA)图像进行回顾性研究。结果 :患眼眼底后极部可见视网膜下 4个至近百个圆形病灶 ,呈灰黄色或黄白色 ,直径 5 0～ 5 0 0 μm。FFA显示活动性病灶造影早期呈高荧光或低荧光 ,后期渗漏 ;非活动性病灶呈透见荧光。CNV大多为 1个 ,平均直径 884 .31μm。 1例 1只眼用糖皮质激素和光动力疗法 (photodynamictherapy ,PDT)治疗 ,视力明显提高 ,CNV缩小。结论 :MFC是导致CNV的病因之一。FFA可用于诊断病灶和CNV。糖皮质激素可能有助于控制炎症、减缓CNV的生长。对MFC合并黄斑中心凹下CNV ,可选择PDT治疗。Objective: To explore the clinical characteristics and therapeutic options of multifocal choroiditis (MFC) with choroidal neovascularization (CNV). Methods: During the period of 2002～2004, medical records and FFA images of 19 patients (20 eyes) of MFC with CNV were retrospectively studied. Results: Many subretinal lesions were found in posterior pole in all of these eyes. On FFA, active lesions showed hyperfluorescence or hypofluorescence at the early phase and fluorescein leakage at the late phase. Inactive lesions showed window defect fluorescence. In most of these eyes only one CNV was found. The average size of CNV was 884.31μm. One patient received systemic steroid and photodynamic therapy (PDT), resulting in a significant improvement in visual acuity, reduction of CNV. Conclusion:MFC was one of the causes of CNV. FFA could help to detect the lesions and CNV. Corticosteroids might help to control inflammation and slow down the growth of CNV. Photodynamic therapy might be a therapeutic option for subfoveal CNV associated with MFC.

关 键 词：CNV 病灶 诊断 多灶性 脉络膜炎 治疗 脉络膜新生血管 合并 缩小 减缓 

分 类 号：R774[医药卫生—眼科] R772[医药卫生—临床医学]