肺癌所致神经系统副肿瘤综合征15例临床分析  

Clinical analysis of 15 patients with paraneoplastic neurological syndromes caused by lung cancer

作　　者：肖卫忠[1] 李坚[1] 隋伟[1] 樊东升[1] 张欣宇[1] 李美琳[1] 康德宣[1] 

机构地区：[1]北京大学第三医院神经科,北京100083

出　　处：《肿瘤防治杂志》2004年第11期1174-1175,共2页China Journal of Cancer Prevention and Treatment

摘　　要：目的 :探讨肺癌所致神经系统副肿瘤综合征 (paraneoplasticneurologicalsyn dromes,PNS)的临床特征及对早期诊断的意义。方法 :对 15例患者的临床资料、影像学、病理及电生理检查进行回顾性分析。结果 :15例患者神经系统损害主要表现为肌无力综合征 4例 ,周围神经病 4例 ,多发性肌炎 3例 ,肌萎缩侧索硬化 2例 ,脑干炎 1例 ,边缘性脑炎 1例。肺癌的类型主要为小细胞肺癌。结论 :肺癌所致神经系统副肿瘤综合征临床表现复杂 ,可发生于肺癌诊断之前 ,临床极易误诊 ,但可协助对肺癌的早期诊断。OBJECTIVE:To discuss the clinical features of paraneoplastic neurological syndromes(PNS) caused by lung cancer in order to improve the early diagnosis on PNS.METHODS:We analyzed the clinical manifestations, image, pathology and electroneuromyography of the 15 patients diagnosed as PNS retrospectively.RESULTS:There were 4 cases of Lambert-Eaton’s myasthenia syndromes (LEMS), 4 peripheral neuropathy, 3 polymyositis, 2 amyotrophic lateral sclerosis(ALS), 1 encephalitis of brain stem, 1 paraneoplastic limbic encephalopathy(PLE) in the group. The main type were small cell lung cancer(SCLC).CONCLUSIONS: The manifestations of PNS were complicate. It can occur before lung cancer. It is misdiagnostics easily in clinical work, but it can help the early diagnosis on lung cancer.

关 键 词：肺肿瘤诊断 肺肿瘤/并发症 类肿瘤综合征/并发症 神经系统肿瘤 

分 类 号：R734.2[医药卫生—肿瘤]