凋亡与肿瘤及其治疗进展  

Progress in apoptosis,cancer and its therapy

作　　者：周彩虹[1] 黄启福[2] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤医院,北京100021 [2]北京中医药大学病理学教研室,北京100029

出　　处：《中国病理生理杂志》2004年第11期2124-2133,共10页Chinese Journal of Pathophysiology

摘　　要：Apoptosis, a common and evolutionarily conserved property of all metazoan,is an essential part of life. The loss of cellular homeostasis balance is a character of tumor. The mitochondria (the intrinsic pathway) and the death receptors (the extrinsic pathway) are two major signal transduction pathways. With elucidation of the apoptotic molecular mechanism, some key proteins and genes related with apoptosis had been as the molecular targets for anticancer new drugs. There is the fundamental signficance to research further both apoptotic molecular mechanism and tumor therapy. [Apoptosis, a common and evolutionarily conserved property of all metazoan,is an essential part of life. The loss of cellular homeostasis balance is a character of tumor. The mitochondria (the intrinsic pathway) and the death receptors (the extrinsic pathway) are two major signal transduction pathways. With elucidation of the apoptotic molecular mechanism, some key proteins and genes related with apoptosis had been as the molecular targets for anticancer new drugs. There is the fundamental signficance to research further both apoptotic molecular mechanism and tumor therapy. [

关 键 词：细胞凋亡 线粒体 死亡受体 肿瘤治疗 

分 类 号：R363[医药卫生—病理学]