人胃癌组织中GABA_B受体的免疫组化研究  

GABA_B receptor expression in human gastric cancer

作　　者：朱人敏[1] 秦苏堤[1] 何小平[1] 汪芳裕[1] 

机构地区：[1]南京南京军区南京总医院,210002

出　　处：《解放军医学杂志》2004年第11期958-960,共3页Medical Journal of Chinese People's Liberation Army

摘　　要：目的　探讨人胃癌组织γ 氨基丁酸 (GABA)B型受体 1(GABABR1)和GABAB型受体 2 (GABABR2 )的表达。方法　随机选取30例胃癌手术标本 ,采用免疫组化法检测GABABR1和GABABR2的表达 ,同时探讨它们与胃癌的临床病理学特征 ,包括性别、部位、浸润程度、分化程度、TNM分期、淋巴结转移的关系。结果　与正常胃黏膜组织比较 ,胃癌组织中GABABR1和GABABR2阳性表达明显增加 (P <0 0 5 ) ,但二者与胃癌的临床病理学特征均无明显相关(P >0 0 5 )。结论　GABABR表达异常可能与胃癌的发生有密切关系 ,但这并不是判断胃癌预后的独立指标。Objectives This study was to evaluate GABA BR (including GABA BR1 and GABA BR2) expression in human gastric cancer. Methods Thirty randomly chosen patients with gastric cancer who underwent surgical treatment were entered into the current study. Immunohistochemistry was carried out to determine the expression of GABA BR. Results Immunohistochemistry analysis showed that the scores of GABA BR1 and GABA BR2 in human gastric cancer tissue increased apparently compared with the adjacent normal tissue(P<0.05). In human gastric cancer tissue, the positive expressions of GABA BR1 and GABA BR2 showed little correlation with the clinical-pathological character of the cancer. Conclution The abnormality of the GABA BR1 and GABA BR2 expressions might contribute to the pathogenesis of human gastric cancer.

关 键 词：受体 GABA—B 免疫组织化学 胃肿瘤 

分 类 号：R735.2[医药卫生—肿瘤]