早期宫颈癌与自由基的关系  

The Relationships between Early Carcinoma of Cervix and Free Radical

作　　者：初忠侠[1] 张伟 温放[3] 强欣[1] 

机构地区：[1]内蒙古大学,内蒙古通辽028041 [2]内蒙古通辽市肿瘤医院放疗科,028000 [3]中国医科大学附属第一医院妇科,辽宁沈阳110001

出　　处：《中国误诊学杂志》2004年第7期1000-1002,共3页Chinese Journal of Misdiagnostics

摘　　要：目的 :探讨早期宫颈癌与自由基的关系。方法 :应用 TBA比色法、黄嘌呤氧化酶法及 DTNB直接显色法分别对 33例早期宫颈癌患者的宫颈组织、癌旁组织及 2 1例正常宫颈组织中的 L PO、SOD及其同功酶及 GSH- Px进行检测。结果 :早期宫颈癌组织中的 L PO含量明显高于癌旁组织及正常宫颈组织 (P<0 .0 5 ,P<0 .0 1) ,T- SOD(总 SOD)、Cu Zn SOD及 GSH- Px活性明显低于癌旁组织及正常宫颈组织 (P<0 .0 5 ,P<0 .0 1) ,Mn SOD活性明显高于癌旁组织及正常宫颈组织 (P<0 .0 5 )。结论 :早期宫颈癌组织中脂质过氧化反应增强 ,但是抗氧化能力不能随之增强 ,提示早期宫颈癌的发生可能与宫颈病变组织中氧化抗氧化失衡有关。检测氧化抗氧化指标对早期宫颈癌的筛选有一定价值。Objective:To explore the relationships between the early carcinoma of cervix uteri and free radical.Methods:Levels of LPO,SOD and GSH Px in the tissues of cervix uteri and paracarcinoma were detcted in33 patients with carcinoma of cervix uteri and 21 healthy control,using TBA DEN, xanthosine, oxidase and DTNB direct colour development.Result:The content of LPO in early carcinnom of cervix uteri′s tissue was higher than that in the normal tissue (P<0.05,P<0.01), T-SOD (total SOD) CuZnSOD and GSH-Px activity was lower than that in cancer′s tissue and normal tissue.Conclusion:The liquid peroxidation increasing and anti-oxidation reducing in early cariciroma of cervix uteri suggested that the occurrence or early cervix uterimight correlate to the imbalance between oxidation and anti-oxidation in the lesion.

关 键 词：宫颈肿瘤 过氧化脂质类/分析 超氧化物歧化酶/代谢 

分 类 号：R737.3[医药卫生—肿瘤]