高压氧对放疗后狗下颌纯钛种植体与骨接触作用的影响  

The effect of hyperbaric oxygen adjunctive treatment on osseointegration of titanium implants in irradiated dog mandibles

作　　者：路正刚[1] 刘洪臣[1] 王所亭[2] 吴殿久[2] 王会信[3] 王东胜[1] 

机构地区：[1]解放军总医院口腔科,北京100853 [2]解放军总医院放疗科 [3]军事医学科学院三所八室

出　　处：《临床口腔医学杂志》2004年第11期666-668,共3页Journal of Clinical Stomatology

摘　　要：目的 :观察高压氧对放疗后狗下颌纯钛种植体与骨接触作用的影响。方法 :8只成年雄性杂种狗 ,拔除双侧下颌第三、四前磨牙和第一磨牙。拔牙后 3个月 ,用电子直线加速器照射一侧下颌无牙区。另一侧不照射作为对照侧。放疗后 3个月 ,狗双侧下颌拔牙区各植入纯钛种植体 4枚 ,手术中、手术前、手术后接受高压氧治疗 ,另外 4只不作处理。种植术后 1.5个月和 3个月高压氧治疗组与未进行高压氧治疗组分别处死 2只动物取材 ,观察种植体与骨组织的接触率及骨小梁体积百分比。结果 :高压氧辅助治疗对放疗侧种植体 -骨接触率无明显影响(P >0 .0 5 )。种植体周围骨小梁体积百分比显著下降 (P <0 .0 5 )。结论Objective:To evaluate the effect of hyper baric oxygen tr eatment on osseointegration of titanium implants in irradiated dog mandibles. Method: Eight male adult dogs underwent extraction of the mand ible third、fourth premolar and first molar .After 3 months, one side of the ma ndible of each dog was irradiated with 15-Gy dose while the other side served as c ontrol. Adjunctive hyperbaric ox ygen(HBO) therapy .Three months after irradiation , four titanium implants wer e inserted in each s ide of the mandible.Four dogs of them received hyperbaric oxygen therapy. .Two dogs were sacrificed at 1.5 and 3 months after implants inserted.Re s ult: Ther e is no obivious change of bone contact surface ratio (BCSR) of implants in irra diated sides after HBO treatment(P>0.05),and the tVsp was o biviously decreased(P= 0.016< 0.05). Conclusion: HB O adjunctiv e therapy have no obvious effect on the osseointegration of titanium implants i n dog irradiated mandibles. [

关 键 词：牙种植体 放疗 种植体-骨接触率 高压氧 

分 类 号：R782.13[医药卫生—口腔医学]