红参中田七氨酸的分离及其生物活性的研究  

Studies On Dencichine In Red Ginseng

作　　者：郑毅男[1] 松浦幸永 刘大有[3] 张东明 关谷敬三[4] 奥田拓道[2] 

机构地区：[1]吉林农业大学中药材学院,长春130118 [2]日本爱媛大学医学部第二生化教研室 [3]长春中医学院 [4]日本四国农业试验场

出　　处：《吉林农业大学学报》1993年第2期22-25,共4页Journal of Jilin Agricultural University

摘　　要：红参粉末中发现含有田七氨酸(β-N-oxalo-L-α,β-diaminopropionic acid)又名三七素,该物质是应用离子交换凝胶色谱柱(CM—Sephadex C—25)和快速蛋白质液相色谱柱(FPLCMono Q)分离得到的。我们检查了田七氨酸对豚鼠主动脉收缩作用的影响,在没有组胺或肾上腺素存在的条件卜,既无收缩作用也无松弛作用,它能增益组胺诱导豚鼠主动脉的收缩;但对于肾上腺素却无作用。此外,田七氨酸通过肾上腺素、ADP凝血酶和胶原,均无诱导血小板聚集的作用。田七氨酸对于血管紧张素转换酶也无阻抑作用。It was found that Red Ginseng powder contain dencichine(p-N -oxalo-L-a,p- iamino-pionic acid) which was isolated by successive colume chroma tographies on CM-sephadex C-25 and Mono Q. We examined the effect of dencichine on the contraction of guinea pig aorta. Although it did not induce contraction or relaxation in the absence of histarnin or norepinephrine, it enhanced histamine-induced contraction but not a norepinephrine-induced one. On the other hand, it had no effect on platelet aggregation induced by epinephrine, ADP, thrombin a collagen. It also did not inhibit the angiotension converting enzyme (ACE).

关 键 词：人参 田七氨酸 组胺 豚鼠 红参 

分 类 号：S567.510.1[农业科学—中草药栽培]