焦虑症、抑郁症及焦虑抑郁障碍共病患者执行功能的对照研究  

Executive function in patients with anxiety, depression and comorbidity of anxiety and depression

作　　者：卞清涛[1] 谢光荣[1] 刘哲宁[1] 

机构地区：[1]中南大学湘雅二医院精神卫生研究所

出　　处：《中华精神科杂志》2004年第4期207-210,共4页Chinese Journal of Psychiatry

基　　金：国家自然科学基金资助项目(30270496)

摘　　要：目的探讨焦虑症、抑郁症和焦虑抑郁障碍共病患者执行功能障碍的差异。方法使用威斯康星卡片分类测验(WCST)、汉密尔顿抑郁量表(HAMD)及汉密尔顿焦虑量表(HAMA)对35例抑郁症(抑郁症组)、30例焦虑症(焦虑症组)及30例焦虑抑郁障碍共病(以下简称共病组)患者于治疗前及治疗第6周末进行评定,以30名正常人为对照组。结果 (1)治疗前后抑郁症组、焦虑症组、共病组组间及与对照组的比较,WCST的总测验次数[抑郁症组(86±24)次,(74±24)次;焦虑症组(77±27)次,(69±10)次;共病组(90±25)次,(83±26)次;对照组(60±15)次,(58±13)次]、持续错误数[抑郁症组(24±10)次,(21±9)次;焦虑症组(25±13)次,(19±6)次;共病组(28±14)次,(26±11)次;对照组(19±8)次,(17±7)次]和非持续错误数[抑郁症组(36±19)次,(27±17)次;焦虑症组(27±17)次,(25±9)次;共病组(31±19)次,(30±19)次;对照组(16±8)次,(15±8)次],差异有显著性:意义或非常显著性意义(P<0.05或P<0.01),各测验次数由高到低依次为共病组、抑郁症组、焦虑症组、对照组;(2)治疗后抑郁症组、焦虑症组、共病组WCST的总测验次数、持续错误数和非持续错误数均低于治疗前,差异有显著性意义(P<0.05);(3)治疗前后HAMD与HAMA减分值与WCST减分值相关性分析,抑郁症组、焦虑?Objective To explore the difference of executive function among patients with anxiety, depressive disorders and comorbidity of anxiety and depression . Methods Patients with depression (n = 35) , anxiety disorder ( n = 30 ) , depression comorbid of anxiety (n = 30) and normal controls ( n = 30) were tested using the Wisconsin Card Sorting Test ( WCST), Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA). And the patients were re-measured after 6-week treatment. Results The patients with depression, anxiety, and comorbidity of anxiety and depression, both pre- and post-treatment, performed significantly worse than the controls on the total sorting cards, persistent errors and random errors of WCST ( P < 0. 05 or P < 0. 01) , and patients with depression comorbid of anxiety performed worst All groups of patients made progress on the WCST scores after treatment ( P < 0.05 ) . There were no relationships between reductions of HAMD, HAMA scores and reductions of WCST total sorting cards, persistent errors and random errors after treatment Conclusions It is suggested that the executive functions in patients with depression, anxiety, and depression comorbid anxiety be impaired.

关 键 词：抑郁症 焦虑症 共病 焦虑抑郁 对照组 患者 执行功能 分值 错误 障碍 

分 类 号：R749.4[医药卫生—神经病学与精神病学]