正常人口服绞股蓝前后常氧与缺氧时心、肺阻抗血流图的观察  

Observations on Impedance Cardiogram and Impedance Pneumogram During Normoxia and Hypoxia Before and After Administration of Gypenosides in Normal Subjects

作　　者：陈刚[1] 汪雄[1] 李莉[1] 

机构地区：[1]郧阳医学院病理生理教研室

出　　处：《郧阳医学院学报》1995年第1期1-3,50,共4页Journal of Yunyang Medical College

基　　金：湖北省卫生厅科研课题

摘　　要：用无创性心阻抗血流图与肺阻抗血流图法研究了正常人口服绞股蓝总甙片（ＧＰｓ）前后常氧与缺氧时心脏及体、肺循环的功能变化。实验发现，正常人口服ＧＰｓ２２ｄ后Ｑ－Ｚ间期及Ｑ－Ｚ间期指数显著缩短，Ｈｅａｔｈｅｒ指数（ＨＩ）显著增加。服药前缺氧时Ｑ－Ｂ间期（Ｑ－Ｂ）及其指数（Ｑ－ＢＩ）、Ｑ－Ｂ／Ｂ－Ｙ比值、肺动脉压（Ｐｐａ）、肺血管阻力及心率（ＨＲ）显著增加，而Ｂ－Ｙ间期、Ｈｓ、心搏量、左心射血前期、左心射血时间、Ｑ－Ｘ间期、Ｃｄｚ／ｄｔｍａｘ以及ＨＩ显著减少：服药后再次缺氧时，Ｑ－ＢＩ，Ｐｐａ、ＨＲ及Ｈｓ的变化程度显著低于服药前缺氧时，服药前缺氧时的其他变化此时不再出现。结果表明，服用ＧＰｓ可增强正常人心肌收缩力，改善缺氧时的心脏功能，抑制缺氧性肺动脉高压。The function of heart, systemic and pulmonary circulation was examined by impedance cardiographyand impedance pneumography during normoxia and hypoxia in 14 healthy young men before and after 22 days of oral administration of Gypenosides(Gps), saponins extracted from Gynostemma pentaphyllum(Thunb) Makino. Gps increased Heather index (HI) and reduced Q-Z interval and Q-Z interval index (Q-ZI). Hypoxic ventilation caused increases in Q-B interval(Q-B) and Q-B/BY ratio,pulmonary arterial pressure(Ppa), pulmonary vascular resistance and heart rate(HR), and decreases in R-Y interval (B-Y), amplitude of the S wave(Hs), stroke volume, left ventricular prejection and ejection time,Q-X interval, Cdz/dtmax and HI before administration of Gps. However after Gps hypoxia had fewer effects on Q-BI Ppa, HR and Hs as compared with pre-Gps, and had no effect on the other parameters. These results indicate that Gps increase myocardial contractility, improve heart function in hypoxia and inhibite hypoxic pulmonary hypertension.

关 键 词：口服 绞股蓝 常氧 缺氧 心阻抗血流图 肺阻抗血流图 肺循环功能 体循环功能 

分 类 号：R364.4[医药卫生—病理学]