立体定向伽玛刀放射外科治疗顽固性癫痫的临床研究  

The Chinical Application of Stereotactic Gammakninfe Radiosurgery in Treatment of Obstinate Epilepsy

作　　者：王宏伟[1] 张国荣[1] 李明洙[1] 刘沙[1] 朱利峰[1] 

机构地区：[1]内蒙古医学院附属医院头部伽玛刀治疗研究中心,内蒙古呼和浩特010050

出　　处：《内蒙古医学杂志》2004年第10期752-754,共3页Inner Mongolia Medical Journal

摘　　要：目的 :采用OUR -XGD型旋转式伽玛刀对脑内某些靶点结构行立体定向放射毁损治疗顽固性癫痫 ,探讨这种方法的疗效。方法 :选择诊断明确的顽固性癫痫病人 ,术前经EEG、BEAM及长程多导脑电、MRI、SPECT等检查 ,根据脑电图、脑功能代谢、脑影像学等检查结果 ,结合发作前及发作时的临床表现进行综合分析 ,对定位明确的局限性致痫灶 ,行伽玛刀治疗。结果 :伽玛刀治疗顽固性癫痫病人 15例 ,随访期 6～ 30个月 (平均 12个月 )。停止发作 8例 ,发作次数明显减少 4例 ,大发作变为小发作 2例 ,无变化 1例 ,无发作加重及死亡病例。有效率 90 %以上。无明显并发症。结论 :经短中期随访结果证明 ,立体定向伽玛刀放射外科是一种无创性治疗顽固性癫痫的安全、有效的治疗手段 ,对有明确非进行性病灶者疗效显著 ,对于功能性病灶 ,致痫灶的精确定位是治疗的关键。随着致痫灶定位技术的进一步发展 ,其疗效将进一步提高。Objective: To study the efficacy and value of application of stereotactic Gammaknife radiosurgery in treatment of obstinate epilepsy. Menthods: 15 patients with confirmed obstinate epilepsy were treated on OUR-XGD Gammaknife radiosurger y therapy.Their localized foci were determined by EEG,BEAM,MRI examinations and clinical features.Results: The foolw-up time was 6 to 30 months (median follow up time of 12 months).8 of 15 cases were cured,6 improved and 1 ineffective.The effective rate was over 90%.There were no obvious complications.Conclusion: The steretactic Gammaknife radiosurgery is a simple ,safe and effective method in treatment of obstinate epilepsy. Accurate location is the key to improve effectiveness and decrease recurrence rate.

关 键 词：顽固性癫痫 伽玛刀 

分 类 号：R742.1[医药卫生—神经病学与精神病学]