番茄红素对实验性肺纤维化大鼠血浆TNF-α、NO、MDA含量及SOD活性的影响  

Effects of lycopene on plasma concentration of TNF-α, NO, MDA and SOD activity in a rat model of pulmonary fibrosis

作　　者：周昌华[1] 蔡美英[1] 魏大鹏[1] 余俊辉[1] 张莉[2] 甘靖[3] 罗文君[3] 

机构地区：[1]四川大学华西基础医学与法医学院免疫学教研室,四川成都610041 [2]华西药学院 [3]华西临床医学院

出　　处：《西部医学》2004年第4期293-295,共3页Medical Journal of West China

摘　　要：目的　考察番茄红素对实验性肺纤维化大鼠血浆 TNF-α、NO、MDA含量及 SOD活性的影响。方法　 6 0只 SD大鼠随机分为正常对照组 (C组 )、模型组 (M组 )和番茄红素干预组 (L组 ) ,每组各 2 0只。 M组和 L组采用博莱霉素 (BL M)经气管注射建立大鼠肺纤维化模型 ,造模当日起 L组每天用番茄红素油树脂灌胃 ,3、7、14和 2 8d处死大鼠采集血浆 ,测定 TNF-α、NO、MDA含量及 SOD活性。结果　与 M组相比 ,L组各时间段 TNF-α、NO、MDA含量降低 (7、14、2 8d,TNF-α:P<0 .0 1;3d,NO、MDA:P<0 .0 5 ) ,SOD活性增高 (2 8d,P<0 .0 5 )。结论　番茄红素能够降低实验性肺纤维化大鼠血浆 TNF-α、NO、MDA含量 ,提高 SOD活性 。Objective To investigate the effects of lycopene on plasma TNF-α, NO, and MDA concentration and SOD activity in a rat model of pulmonary fibrosis.Methods sixty SD rats were randomly divided into 3 groups:normal control (C group), pulmonary fibrosis (M group), and lycopene-treatment (L group), with 20 rats in each group.The model of pulmonary fibrosis was established through intratracheal injection of bleomycin.The rats in L group were treated by lycopene every day after BLM injection.The plasma TNF-α, NO, MDA concentration and SOD activity were measured at 3, 7, 14, and 28 days after bleomycin injection respectively.Results The plasma TNF-α, NO, MDA concentration in L group decreased and SOD activity increased significantly as compared with M group.Conclusion Lycopene is effective in obviating BLM-induced pulmonary damage in rats by reducing plasma TNF-α, NO, MDA concentration and enhancing SOD activity.

关 键 词：肺纤维化 番茄红素 博莱霉素 

分 类 号：Q95-331[生物学—动物学]