NIT-Ⅵ对豚鼠右心室乳头状肌慢反应动作电位的影响  

Effects of NIT-Ⅵ on slow action potentials of guinea pig papillary muscles

作　　者：温洪涛[1] 谢华[2] 胡香杰[2] 张贵卿[2] 

机构地区：[1]郑州大学第一附属医院消化内科,郑州450052 [2]郑州大学基础医学院药理学教研室,郑州450052

出　　处：《郑州大学学报（医学版）》2004年第6期1012-1014,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的 :观察尼群地平衍生物NIT -Ⅵ对离体豚鼠右心室乳头状肌慢反应动作电位 (SAP)的影响。方法 :离体豚鼠右乳头状肌经含异丙肾上腺素或组织胺的高K+ 台氏液 (K+ 浓度 2 5mmol/L)灌流诱发SAP后 ,采用累积浓度给药法依次给予NIT -Ⅵ 3× 10 -9mol/L ,3× 10 -8mol/L和 3× 10 -7mol/L。采用标准玻璃微电极技术记录慢反应动作电位。记录给药前后的SAP振幅 (APA) ,0期最大除极速率 (vmax) ,复极 5 0 %和 90 %的时程 (APD5 0和APD90 )。结果 :NIT -Ⅵ 3× 10 -9mol/L、3× 10 -8mol/L、3× 10 -7mol/L可明显降低高钾除极时异丙肾上腺素、组织胺等诱发的SAP的APA、vmax,缩短APD5 0和APD90。结论 :NIT -Aim: To study the effects of the ramification of nitrendipine (NIT-Ⅵ) on the slow action potentials in guinea pig papillary muscles. Methods: Conventional microelectrode technique was used to record the slow action potentials (SAP) of guinea pig papillary muscles. Results: NIT-Ⅵ 3×10 -9 mol/L,3×10 -8 mol/L,3×10 -7 mol/L suppressed the maximal upstrode velocity (v max), action potential amplitude (APA) of SAP induced by histamine and isoprenaline when perfused with KCI 25mmol/L Tyrode's solution, and shortened the action potential duration at 50%, 90% repolarization (APD50, APD90) of SAP. Conclusion: NIT-Ⅵ can block calcium channels in the myocardium.

关 键 词：尼群地平 衍生物 乳头状肌 慢反应动作电位 豚鼠 

分 类 号：R972[医药卫生—药品]