壮肝逐瘀煎抗大鼠肝纤维化的实验研究  被引量：21

perimental study of anti-liver fibrosis of Zhuanggan Zhuyu decoction</em> <p class='article-op'> <span id="bdshare" class="bdshare_t bds_tools get-codes-bdshare baidufx"><span><span class="bds_more" style="display: block; width: 62px; height: 29px; background: url(/images/share.gif) no-repeat!important; padding: 0;"></span></span></span> </p> <p class="article-source"> <a href ='/article/read.aspx?id=10880170' class='btnTitle btnIsView' target='_blank'><img alt='在线阅读' src='/images/btn-read.png'/></a><a class='btnTitle btnIsView' href="javascript:showdown('jJg9rRnRGA4YaXytgRE8aauHJxj324N0OGmh7PyUQWs=')"><img alt="下载全文" src="/images/btn-down.png" /></a> <input id="hiddowninfo" type="hidden" value="jJg9rRnRGA4YaXytgRE8aauHJxj324N0OGmh7PyUQWs="/> </p> <div class="collect" style="display: none"> <h5>我的收藏</h5> <div class="cnt"> <p> 名 称：<input type="text" name="collTitle" id="collSumTitle" /> </p> <p> 注 释：<input type="text" name="collRemark" id="collSumRemark" /> </p> <p style="text-align: center;"> <a href="javascript:void(0)" onclick="g_collectSumOk();"> <img width="65" height="17" src="/images_new/collect_ok.png" alt="完成" /></a> <a href="javascript:void(0)" onclick="g_collectSumCancel();"> <img width="65" height="17" src="/images_new/collect_no.png" alt="取消" /></a> </p> </div> </div> </div> <form name="wxTransfer" method="post"> <input type="hidden" name="lid" value="" /> <input type="hidden" name="sip" value="" /> <input type="hidden" name="date" value="" /> <input type="hidden" name="co" value="" /> <input type="hidden" name="Title_C" value="" /> <input type="hidden" name="Writers" value="" /> <input type="hidden" name="Name_C" value="" /> <input type="hidden" name="Num" value="" /> <input type="hidden" name="Years" value="" /> <input type="hidden" name="Volumn" value="" /> <input type="hidden" name="GCH" value="" /> <input type="hidden" name="Vol" value="" /> <input type="hidden" name="BookID" value="" /> <input type="hidden" name="SubjectNum" value="" /> <input type="hidden" name="SpecialNum" value="" /> <input type="hidden" name="mirrorName" value="" /> <input type="hidden" name="UserID" value="" /> <input type="hidden" name="UserName" value="" /> <input type="hidden" name="sourceID" value="" /> </form> <script type="text/javascript" src="/scripts/transfer.min.js"></script> <div class="article-detail"> <p class='author'><strong>作　　者：</strong><a href='/writer/article.aspx?id=100000007605485' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e6%9e%97%e5%af%bf%e5%ae%81%5d' title='林寿宁[1]'>林寿宁[1]</a> <a href='/writer/article.aspx?id=100000007132278' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e9%bb%84%e8%b4%b5%e5%8d%8e%5d' title='黄贵华[1]'>黄贵华[1]</a> <a href='/writer/article.aspx?id=100000008594141' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e7%8e%8b%e6%8c%af%e5%b8%b8%5d' title='王振常[2]'>王振常[2]</a> <a href='/writer/article.aspx?id=100000011586557' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e9%bb%84%e5%bd%ac%5d' title='黄彬[1]'>黄彬[1]</a> <em> </em></p><p class='organ'><strong>机构地区：</strong><a href='/organ/article.aspx?id=544&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e5%b9%bf%e8%a5%bf%e4%b8%ad%e5%8c%bb%e5%ad%a6%e9%99%a2%e9%99%84%e5%b1%9e%e7%91%9e%e5%ba%b7%e5%8c%bb%e9%99%a2%e6%b6%88%e5%8c%96%e7%a7%91' title='[1]广西中医学院附属瑞康医院消化科,南宁530011'>[1]广西中医学院附属瑞康医院消化科,南宁530011</a> <a href='/organ/article.aspx?id=658548&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e5%b9%bf%e8%a5%bf%e4%b8%ad%e5%8c%bb%e5%ad%a6%e9%99%a2' title='[2]广西中医学院'>[2]广西中医学院</a> <em> </em></p><p class='from'><strong>出　　处：</strong><a href='/journal/summary.aspx?gch=98320A' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=J%3d%5b%e4%b8%ad%e5%9b%bd%e4%b8%ad%e8%a5%bf%e5%8c%bb%e7%bb%93%e5%90%88%e6%b6%88%e5%8c%96%e6%9d%82%e5%bf%97%5d' title='中国中西医结合消化杂志'>《中国中西医结合消化杂志》</a>2004年第5期267-270,共4页<em>Chinese Journal of Integrated Traditional and Western Medicine on Digestion</em></p><p class='fund'><strong>基　　金：</strong>广西壮族自治区自然科学基金资助项目(No;桂科0229047)</p><p class='abstrack'><strong>摘　　要：</strong>[目的]探讨壮肝逐瘀煎抗肝纤维化的作用及其机制。[方法]采用CCl4复合因素大鼠肝纤维化模型,予壮肝逐瘀煎灌胃,观察血清学、形态学及免疫组织化学变化,并进行图像分析及统计学处理。[结果]壮肝逐瘀煎能显著降低大鼠血清透明质酸、层黏连蛋白、Ⅳ型胶原、Ⅲ型前胶原的水平;减轻肝脏炎症及纤维化程度:肝组织胶原面积明显减少;抑制肝组织α-平滑肌肌动蛋白和结蛋白的表达。[结论]壮肝逐瘀煎具有保肝和抗肝纤维化作用,其作用机制可能与抗炎、抑制肝脏星状细胞的活化和增殖有关。<em><abstract>bjective] To investigate the effect and mechanism of Zhuanggan Zhuyu decoction (ZZD) in the treatment of liver fibrosis in rat model. [ Methods]The rat model of liver fibrosis was made by Carbon tetrachloride and combined factors and treated with ZZD. The indexes of hepatofibrosis, morphologic and immunohistochemical staining changes of the liver were observed. Image and statistical analysis were used to testify the results. [Results] After the treatment with ZZD, serum levels of HA, LN, Ⅳ-C and PC Ⅲ were significantly decreased; formation of liver fibrosis was successfully ameliorated; collagen staining positive area was decreased;and expression of α-SMA and HSC was inhibited. [Conclusion] ZZD could protect hepatocyte from injury and prevent the progress of hepatic fibrosis in rats, which may associate with its effect of anti - inflammation and inhibiting the activation and proliferation of HSC.</em></p><p class='subject'><strong>关 键 词：</strong><a href='/zk/search.aspx?key=K%3d%5b%e8%82%9d%e7%a1%ac%e5%8c%96%5d' title='肝硬化'>肝硬化</a> <a href='/subject/article.aspx?id=3482945' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e5%a3%ae%e8%82%9d%e9%80%90%e7%98%80%e7%85%8e%5d' title='壮肝逐瘀煎'>壮肝逐瘀煎</a> <a href='/subject/article.aspx?id=626962' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e5%bd%a2%e6%80%81%e5%ad%a6%5d' title='形态学'>形态学</a> <a href='/subject/article.aspx?id=4699026' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e5%85%8d%e7%96%ab%e7%bb%84%e5%8c%96%5d' title='免疫组化'>免疫组化</a> </p><p class='class'><strong>分 类 号：</strong><a href='/zk/search.aspx?key=C%3dR575.2' title='R575.2'>R575.2</a>[<a href = '/domain/article.aspx?id=493' >医药卫生—消化系统</a>] </p> </div> <div id="content_wzxg" name="wzxg" class="article-graph"> <object width="695" height="250" classid="clsid:D27CDB6E-AE6D-11cf-96B8-444553540000" id="FlashID"> <param value="../flash/relation.swf" name="movie"> <param value="high" name="quality"> <param value="opaque" name="wmode"> <param value="6.0.65.0" name="swfversion"> <param value="dataUrl=/ajax/articlerelativegraph.ashx?id=10880170" name="flashVars"> <embed width="695" height="250" src="../flash/relation.swf" type="application/x-shockwave-flash" quality="high" wmode="opaque" flashvars="dataUrl=/ajax/articlerelativegraph.ashx?id=10880170"> </embed> </object> </div> <div class="article-relate-list"> <div class="relate-list"> <p id="ckwx_br"> </p> <h2 name="ckwx" id="ckwx">参考文献：</h2> <div id="listckwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="2jckwx_br"> </p> <h2 name="2jckwx" id="2jckwx">二级参考文献：</h2> <div id="list2jckwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="ohwx_br"> </p> <h2 name="ohwx" id="ohwx">耦合文献：</h2> <div id="listohwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="yzwx_br"> </p> <h2 name="yzwx" id="yzwx">引证文献：</h2> <div id="listyzwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="2jyzwx_br"> </p> <h2 name="2jyzwx" id="2jyzwx">二级引证文献：</h2> <div id="list2jyzwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="tbywx_br"> </p> <h2 name="tbywx" id="tbywx">同被引文献：</h2> <div id="listtbywx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="xgqklw_br"> </p> <h2 name="xgqklw" id="xgqklw">相关期刊文献：</h2> <div id="listxgqklw"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> </div> </div> <div class="article-about"> <div class="about-box"> <h5 class="name">相关的主题<tt><a class="hide" href="#"></a></tt></h5> <div class="about-list"> </div> </div> <div class="about-box"> <h5 class="name">相关的作者对象<tt><a class="" href="#"></a></tt></h5> <div class="about-list" style="display: none;"> </div> </div> <div class="about-box"> <h5 class="name">相关的机构对象<tt><a class="" href="#"></a></tt></h5> <div class="about-list" style="display: none;"> </div> </div> </div> </div> </div> <script type="text/javascript" src="/scripts/articlerelation.min.js"></script> <script type="text/javascript" src="/scripts/articlerightrelation.min.js"></script> <script type="text/javascript" src="/scripts/articledown.min.js"></script> <div class="layer-box download" id="downloadlayer" style="display: none"> <div class="close"> <a onclick="closedown()" href="javascript:void(0)"> <img src="/images/layer-close.png" width="21" height="21" alt="" /> </a> </div> <h5 class="layer-title">下载全文</h5> <div id="downloadinfo"></div> </div> <div class="layer-box download" id="downloadlayer2" style="display:none;min-height:100px;width:500px;"> <p> <img src="/images/loading2.gif" width="64" height="64"> <span style="font-size:20px;vertical-align:middle;padding-bottom:50px;">正在链接到云南高校图书馆文献保障联盟下载...</span> </p> </div> <script id="bdshare_js" data="type=tools&uid=0" type="text/javascript"></script> <script type="text/javascript"> $(function () { var rd = GetQueryString("rd"); 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