补铁对人体血清转铁蛋白受体水平的影响  

Effects of iron supplementation on human serum level of transferrin receptor

作　　者：田伟[1] 林晓明[1] 

机构地区：[1]北京大学公共卫生学院营养与食品卫生学系,100083

出　　处：《中华预防医学杂志》2004年第5期324-327,共4页Chinese Journal of Preventive Medicine

摘　　要：目的　研究补铁过程血清转铁蛋白受体 (sTfR)值的时相动态变化趋势 ,为sTfR是否可作为观察补铁效果的指标提供依据。方法　 2 0 0 2年 4～ 10月 ,从河北省廊坊市和北京顺义区初筛 94 2名 18～ 4 5岁育龄妇女 ,检测其铁生化指标 ,依现行铁状况评价标准 ,筛检红细胞生成缺铁 (IDE)和缺铁性贫血 (IDA)妇女 ,经知情同意后 ,共有 5 9名妇女完成了自始至终的补铁效果动态观察。采用L 苏糖酸亚铁胶囊 (7mg元素铁 /粒 ) ,IDE妇女隔日服 4粒 ,IDA妇女每日服 4粒 ,补铁 12周 ,分别测定补铁过程中 0、3、6、9和 12周的铁生化指标和sTfR值 ,观察sTfR时相动态变化。结果　IDE和IDA育龄妇女sTfR含量分别为 (2 6 6 2± 10 5 7)nmol/L和 (41 2 5± 2 1 96 )nmol/L ,均显著高于健康者的水平 ;在补铁过程中 ,sTfR呈现以下变化特点 :在IDE期 ,sTfR在补铁后 3周内趋于平稳 ,3周后渐进性降低 ,至12周时接近和达到健康者的水平 ,检测值为 (17 86± 5 5 7)nmol/L ;在IDA期 ,补铁后 3周内sTfR迅速下降 ,3周后缓慢下降 ,至第 9周趋于平稳 ,至 12周时接近和达到健康者的水平 ,检测值为 (19 5 4±5 94 )nmol/L ;sTfR/血清铁蛋白在补铁过程中的变化趋势与sTfR基本平行 ;补铁过程中sTfR与血红蛋白、血清铁蛋白呈负相关 ,与锌卟啉?Objective To study trend of dynamic change in level of serum transferrin receptor (sTfR) in the process of iron supplementation to provide evidence for sTfR in evaluating the efficacy of iron supplementation. Methods Totally, 942 child-bearing-age women aged 18 to 45 years were selceted from Longfang City, Hebei Province and Shunyi County, Beijing. Biochemical indicators of iron metabolism were measured for all of them, including serum levels of ferritin (SF) and zinc protoporphyrin (ZPP), and hemoglobin (Hb). According to the current criteria for assessing iron status, women were screened for iron deficiency erythropoiesis (IDE) or iron deficiency anemia (IDA). Seventy-two women agreed to participate in the study, and 59 of them finished whole dynamic observations with signed informed consent. Four capsules of ferrous L-threonate (containing 7 mg of iron element per capsule) were administed for women with IDE every other day and for women with IDA every day, respectively, for 12 weeks. Serum biochemical indicators and level of sTfR were measured in 0 wk, 3 wk, 6 wk, 9 wk and 12 wk, respectively, during the process of iron supplementation, and their dynamic changes were observed. Results Level of sTfR in women with IDE and IDA was (26.62±10.57) nmol/L and (41.25±21.96) nmol/L, respectively, significantly higher than normal level. During the process of iron supplementation, level of sTfR changed as the following characteristics. In women with IDE, level of sTfR kept stable within the first 3 weeks of iron supplementation, then droped gradually and progressively, reached to normal, with (17.86±5.57) nmol/L, in the 12 wk after iron supplementation. In women with IDA, level of sTfR dropped quickly within the first 3 wk of iron supplementation, then dropped slowly until the 9th wk and kept stable, and reached to normal level in the 12 wk, with (19.54±5.94) nmol/L and a ratio of sTfR/SF of 12.23±4.34. Ratio of sTfR/SF changed as level of sTfR during the process of iron supplementation. Level of sTfR correlated

关 键 词：补铁 妇女 观察 铁状况 血清铁蛋白 健康 转铁蛋白受体 水平 过程 结论 

分 类 号：R151[医药卫生—营养与食品卫生学]