人胃癌淋巴管的超微结构  

ULTRASTRUCTURAL STUDIES ON INITIAL LYMPHATICS OF HUMAN GASTRIC CARCINOMA

作　　者：刘慧冬[1] 赵玲辉[1] 李玉兰[1] 李晓冬[1] 刘海明[2] 张雅芳[1] 

机构地区：[1]哈尔滨医科大学解剖学教研室,哈尔滨150086 [2]解放军211医院,哈尔滨150086

出　　处：《解剖学报》2004年第5期513-516,共4页Acta Anatomica Sinica

基　　金：国家自然科学基金资助项目 ( 3 0 2 70 697) ;黑龙江省自然科学基金资助项目 (D0 1 0 7)

摘　　要：目的　研究人胃癌组织毛细淋巴管的超微结构特点 ,探讨癌细胞淋巴道转移机理。　方法　取人胃癌中心区、周边区及正常区组织块 ,常规制作 ,树脂包埋 ,半薄切片 ,光镜下定位、检出淋巴管经超薄切片 ,电镜观察。　结果　胃癌中心区未见淋巴管。胃癌周边区较正常区毛细淋巴管数量多 ,管腔较大 ,形态不规则 ;毛细淋巴管内皮细胞破坏 ,细胞器有明显改变。正常区毛细淋巴管的分布和形态结构未见明显变化。　结论　人胃癌周边区淋巴管的数量、形态及超微结构均有变化 ;胃癌细胞进入淋巴管的主要途径可能是经内皮细胞破坏处和连接开放处。Objective To study the ultrastructural features of initial lymphatics of gastric carcinoma,to discuss the metastasis mechanism of malignant cells by lpmphatics. Methods The postoperative samples of patients with gastric cancer were obtained in center,peripheral and normal region of cancer.Common Resin-embedded specimens were made.Lymphatics were located by hemithin sections under light microscope and observed by ultrathin sections under electron microscope. Results There were no lymphatics in carcinomatous centre region.Compared with normal region,there were more initial lymphatics in peripheral region of gastric carcinoma.The lumina were dilated and irregular and the endothelium were destroyed;The organelle of endothelial cells changed obviously.The distribution and morphology of the lymphatics did not changed evidently in the normal region.Conclusion These results suggest that amount,ultrastructure and morphology of lymphatics changed in peripheral region of carcinoma;Gastric cancer cells may invade lymphatics via destroyed parts of endothelium or interendothelial openings.

关 键 词：毛细淋巴管 超微结构 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]