结缔组织生长因子在肾间质纤维化中的表达及其调控  

Expression and modulation of connective tissue growth factor in renal interstitial fibrosis

作　　者：刘燕[1] 樊均明[1] 

机构地区：[1]四川大学华西医院肾内科,四川成都610041

出　　处：《中国病理生理杂志》2004年第9期1725-1728,共4页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.30170437)

摘　　要：CTGF, a member of the CCN family of immediate early genes, is a recently discovered profibrotic growth factor, which is involved in many pathophysiologic procedures. CTGF acts as a downstream effector of TGF-β acting on interstitial cells to enhance the progression of fibrotic renal diseases. It has been shown that CTGF gene expression can be induced or blocked by some kinds of cytokine and drugs. It is an interesting candidate target for future intervention strategies of renal interstitial fibrosis. [CTGF, a member of the CCN family of immediate early genes, is a recently discovered profibrotic growth factor, which is involved in many pathophysiologic procedures. CTGF acts as a downstream effector of TGF-β acting on interstitial cells to enhance the progression of fibrotic renal diseases. It has been shown that CTGF gene expression can be induced or blocked by some kinds of cytokine and drugs. It is an interesting candidate target for future intervention strategies of renal interstitial fibrosis. [

关 键 词：结缔组织生长因子 转化生长因子Β 肾间质纤维化 

分 类 号：R363[医药卫生—病理学]