伽玛刀治疗生长激素型垂体腺瘤的临床疗效观察  

Efficacy of gamma knife radiosurgery in treatment of growth hormone-secreting pituitary adenoma

作　　者：王美华[1] 刘鹏[1] 刘阿力[1] 罗斌[1] 孙时斌[1] 

机构地区：[1]北京市神经外科研究所伽玛刀中心,100050

出　　处：《中华医学杂志》2003年第23期2045-2048,共4页National Medical Journal of China

摘　　要：目的　观察和评价Leksell伽玛刀治疗生长激素型垂体腺瘤的疗效。方法　应用伽玛刀治疗了 14 9例生长激素型垂体腺瘤患者 ,肿瘤平均体积 2 36cm3(0 11～ 12 7cm3) ;肿瘤周边平均剂量 2 0 87Gy(10～ 30Gy)。对 12 4例患者进行了平均 30个月 (6～ 72个月 )的随访。结果　 74例(6 4 9% )患者的血清生长激素 (GH)值恢复正常水平 ,2 3例 (18 5 % )患者的血清GH值较伽玛刀治疗前降低 ,但仍高于正常值 ;84例 (6 7 6 % )的患者肿瘤缩小 ,4 0例 (32 3% )的患者肿瘤无变化 ,1例治疗后出现复视 ,无其他并发症。结论　伽玛刀立体定向放射外科治疗生长激素型垂体腺瘤 ,对肿瘤控制及内分泌改善是有效和安全的。Objective To evaluate the efficacy of gamma knife radiosurgery (GKS) in treatment of growth hormone (GH)-secreting pituitary adenoma.Methods 149 patients with GH-secreting pituitary adenoma, 97 males and 52 females, aged 42.8 (12～72 years), with a course of 6～240 months (72.5 months) and with the mean volume of tumor of 2.36 cm 3 (0.11～12.7 cm 3) were treated by GKS.The mean dose to tumor margin was 20.87 Gy (10～30 Gy).124 of them were followed up for 30 months (6～72 months).Results The serum GH returned normal in 74 patients (64.9%) and declined in comparison with the level before radiosurgery in 23 patients (18.5%). The tumor volume was reduced in 84 patients (67.7%) and remained unchanged in 124 patients (32.4%).Ambiopia appeared in one patient.No other complication was found during the follow-up.Conclusion GKS is safe and effective on the treatment of GH-secreting pituitary adenoma.

关 键 词：伽玛刀 生长激素型 垂体腺瘤 临床疗效 放射疗法 适应证 诊断标准 

分 类 号：R736.4[医药卫生—肿瘤] R730.55[医药卫生—临床医学]