血管内皮生长因子m-RNA表达与大肠癌生长转移的关系  

The Relationship between Express of Vascular Endothelial Growth Factor mRNA and Colorectal Cancer Growth and Metastasis

作　　者：朱云松[1] 陆华生[1] 李玉明[1] 许利华[2] 杨大明[2] 姚登福[1] 

机构地区：[1]南通医学院第二附属医院消化内科,南通226001 [2]南通医学院附属医院

出　　处：《南通医学院学报》2004年第2期175-176,共2页ACTA Academiae Medicinae Nantong

摘　　要：目的 :探讨血管内皮生长因子表达与大肠癌组织的生长、侵袭和转移关系。方法 :应用逆转录聚合酶链(RT- PCR)法 ,对 2 3例大肠癌组织、远癌组织及 16例结肠息肉的血管内皮生长因子基因进行扩增。结果 :2 3例大肠癌组血管内皮生长因子 m RNA阳性率 6 5 .2 2 % ,明显高于远癌组 (2 1.74 % )及结肠息肉组 (18.75 % )。差异有显著性 (P<0 .0 1)。且与大肠癌临床病理分期有关。结论 :血管内皮生长因子 m RNA可作为大肠癌生长。Objective:To explore the express significance of vascular endothelial growth factor (VEGF) in colorectal growth and metastasis.Methods:The VEGF gene was amplified by nested reverse transcription polymerase chain reaction (RT-PCR) in colorectal cancerous tissues, distal cancerous tissues and colon polypus.Results:Of the 23 colorectal cancer patients, the expressions of VEGF-mRNA were 65.22% in cancerous tissues,21.74% in cancerous tissue and 18.75% in colon polypus in 16 cases. The former was significantly higher than the latter (P<0.01). There was correlation with tumor stages in VEGF gene expression.Conclusion:The VEGFmRNA expression can be regarded as indexes for colorectal cancer growth ,prognosis and metastasis.

关 键 词：大肠癌 血管内皮生长因子基因 生长转移 

分 类 号：R735.34[医药卫生—肿瘤]