同型半胱氨酸血症与缺血性脑血管病的相关性研究  

The Relationship of plasma homocysteine and ischemic cerebrovascular diseases

作　　者：靳轶敏[1] 胡洁[1] 乔芳芳[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院第二住院部

出　　处：《中国康复医学杂志》2004年第6期455-456,共2页Chinese Journal of Rehabilitation Medicine

基　　金：黑龙江省科技攻关计划项目资助(GB02C137-03)

摘　　要：目的:研究血浆同型半胱氨酸(Hcy)与缺血性脑血管病的关系。方法:采用荧光偏振免疫分析方法测定55例缺血性脑血管病患者和34例健康者血浆Hcy水平,同时记录入院时神经功能缺损评分(NIHSS)、血压、血糖,分析其关系。结果:①病例组与对照组的血浆Hcy水平有显著性差异,病例组高于对照组。②脑血管病组中高Hcy血症者和正常Hcy者的入院评分有显著性差异;伴有高血压、糖尿病者和血压、血糖正常者的入院评分无显著性差异。结论:高同型半胱氨酸血症与缺血性脑血管病的危险性增加有关,并且增加其严重程度。Objective:To study the relationship of plasma homocysteine and ischemic cerebrovascular diseases.Method:Plasma homocys teine(Hcy) level of 55 cases with ischemic cerebrovascular diseases and 34 healthy subjects was measured by using immuno-fluorescence polarization.Meanwhile,the evaluation of their neurological impairments was recorded and the blood pressure and blood sugar of patients in case group were measured when they were hospitalized. Result:①Plasma Hcy level in cases was significantly higher than that in controls.②There was a significant difference between the evaluation score for high blood Hcy patients and that for normal ones in case group.But no significant difference was observed when it involved with blood pressure and blood sugar.Conclusion:The total plasma Hcy level is related to both ischemic cerebrovascular diseases and its severity.Author′s address The First Affiliated Hospital, Haerbin Medical University, 150001

关 键 词：同型半胱氨酸血症 缺血性脑血管病 相关性 荧光偏振免疫分析方法 测定 

分 类 号：R743[医药卫生—神经病学与精神病学]