基因突变斑马鱼骨纳米力学性能的改变  

Variation of Nanomechanical Properties in the Gene Mutated Zebrafish Bone

作　　者：马晨[1] 崔福斋[1] 王秀梅[1] 

机构地区：[1]清华大学材料系生物材料实验室,北京100084

出　　处：《材料导报》2004年第7期65-68,共4页Materials Reports

基　　金：国家自然科学基金(No.20031010)

摘　　要：在基因突变的 dml 型斑马鱼中第一次发现纳米力学性能的明显改变。与野生型斑马鱼骨相比,基因突变的 dml 型斑马鱼的纳米压痕的硬度和弹性模量均大大降低。断裂表面的 SEM 形貌照片进一步揭示了在基因突变的鱼骨中,正常骨的夹板状结构不再存在,形成的微裂纹使力学性能减小,与正常鱼相比,骨的脆性明显增加。The paper first reveals significant variations of nanomechanical properties between gene mutateddml zebrafish and wild type zebrafish.Nanoindentation results disclose dml zebrafish bone has much lower hardnessand elastic modulus.SEM morphology of fracture surfaces further reveals the plywood-like structure of the wide typebone does not exist in the gene mutated dml bone,while the gene mutated dml bone has many microcracks,whichallows the reduction of nanomechanical properties and the increasing of brittleness.

关 键 词：基因突变 斑马鱼 力学性能 纳米压痕 骨 生物力学 

分 类 号：Q66[生物学—生物物理学]