5-羟色胺2A受体基因多态性与精神分裂症患者迟发性运动障碍的关联分析  

Assocation between the serotonin 2A receptor gene and tardive dyskinesia in chronic schizopnrenia

作　　者：张晓斌 沙维伟 候钢[2] 

机构地区：[1]江苏省扬州五台山医院,225003 [2]南京医科大学附属脑科医院

出　　处：《上海精神医学》2004年第3期145-148,共4页Shanghai Archives of Psychiatry

摘　　要：目的　探讨 5 羟色胺 2A(5 HT2A)受体基因A14 38G多态性与精神分裂症伴迟发性运动障碍 (TD)的相关性。方法　先用异常不自主运动量表 (AIMS)评定精神分裂症男性患者有无TD及其严重程度 ,再对 4 2例符合TD(AIMS总分≥ 3分 )者和与TD组严格相匹配的 5 1例非TD者 ,采用简明精神病评定量表 (BPRS)评定精神症状 ,应用聚合酶链反应 限制性片段长度多态性方法分析 5 HT2A受体基因的分布频率。结果　 (1)经吻合度检验 ,TD组、非TD组的 5 HT2A受体基因A14 38G多态性位点的基因型分布均符合Hardy Weinberg平衡法则 (χ2 值分别为 0 0 6、0 0 2 ,υ均 =1,P均 >0 0 5。 (2 )TD组与非TD组的基因型总体分布的差异无显著性 (χ2 =4 37,υ =2 ,P >0 0 5 ) ,等位基因频率分布的差异有显著性 (χ2 =4 36 ,υ=1,P <0 0 5 )。 (3)TD组的AIMS和BPRS的评分分别为 (6 5± 1 8)分和 (5 1 2± 7 8)分 ,非TD组分别为 0分和 (5 0 3± 7 4 )分 ,差异无显著性 (P >0 0 5 )。结论　 5 HT2A受体基因的A14 38G多态性可能与男性精神分裂症患者的TD相关联。Objective: The present study was to investigate whether the genetics variation of the serotonin 2A (5-HT_(2A)) receptor gene was associated with tardive dyskinesia (TD) in chronic schizophrenic patients receiving long-time typical antipsychotics. Methods: 42 male schizophrenic Patients with TD, 51 without TD were entered the study. The diagnosis of TD was made according to the Abnormal Involuntary Movement Scale (AIMSA) score, with the AIMS score≥3 as having TD. Psychiatric symptoms were rated using the Brief Psychiatric Rating Scale (BPRS). The 5-HT_(2A) receptor gene polymorphism was analyzed with the polymerase chain reaction-restriction fragment length polymorphism. Results: (1) The distributions of genotypes in patients with TD or without TD all followed Hardy-Weinberg law (χ~2=0.06、0.02, all υ=1, all P>0.05). (2) There were no significant differences of genotypic distribution between the TD group and the without TD group (χ~2=4.37, υ=2, P>0.05). (3) There were no significant differences in clinical demographic characteristics and scores of clinical assessment between the patients with TD and those without TD (P>0.05). Conclusion: The may be relationship betweer A1438G polymor phisms of serotonin 2A receptor gene and tardive dyskinesia in male chronic schizophrenia.

关 键 词：5-羟色胺2A受体 基因多态性 精神分裂症 迟发性运动障碍 相关性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]