GNB3基因C825T多态性与中国人群出血性脑卒中发病无关  

Lack of association of G-protein subunit gene C825T polymorphism with hemorrhagic stroke in Chinese population

作　　者：赵勇[1] 王建春[1] 孙慧[2] 马丽媛[3] 孙金凤[2] 邵建华[1] 刘力生[3] 

机构地区：[1]山东省立医院保健科,山东济南250021 [2]济南市中心医院,山东济南250013 [3]北京阜外心血管病医院,北京100037

出　　处：《中风与神经疾病杂志》2004年第4期314-316,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的　探讨 G蛋白 β3亚基 ( GNB3)基因 C82 5 T多态性与中国人群出血性脑卒中之间的关系。方法　利用 PCR和分子杂交技术对该位点在中国人群出血性脑卒中患者 ( 2 0 2人 )中的分布进行检测和分析 ,并与无脑血管病变的人群 ( 190人 )进行比较。结果　 C82 5 T多态性位点在两组人群中的分布均符合 Hardy- Weinberg遗传平衡定律。CC、CT、TT3种基因型在病例组中分布频率分别为 2 7.2 3%、4 3.0 7%和 2 9.70 % ,对照组中分别为 2 8.95 %、4 8.4 2 %和 2 2 .6 3% ;两组人群 82 5 T等位基因频率分别为 5 1.2 4 %和 4 6 .84 % ,分布均无统计学明显差异 ( P>0 .0 5 )。结论　 GNB3基因 C82 5Objective To determine the relationship between C825T polymorphism in G protein beta 3 subunit (GNB3) gene and hemorrhagic stroke inChinese population.Methods 202 patients with hemorrhagicstroke and 190 controls without stroke were surveyed by polymerase chain reaction (PCR) and corresponding probe hybridization.Results C825T polymorphism was in agreement with Hardy-Weinberg equilibrium in both groups.Theprevalence rates of CC,CT,TT genotypes were 27.23%,43.07% and 29.70% in patients;and 28.95%,48.42% and 22.63% in controls,respectively.The 833C allele frequencies were 0.74% in patients and 1.05% in controls.No significant differences in both genotypes and allele of C825T polymorphism were observed between cases and controls.Conclusions The C825T polymorphism of GNB3 gene may notbe a genetic marker of hemorrhagic stroke in Chinese population.

关 键 词：GNB3基因 C825T 基因多态性 中国人 出血性脑卒中 

分 类 号：R743.34[医药卫生—神经病学与精神病学] R394[医药卫生—临床医学]