吸烟、饮酒与食管癌p53基因改变的Meta分析  

Meta-analysis on the relationship between tobacco smoking, alcohol drinking and p53 alteration in cases with esophageal carcinoma

作　　者：王波[1] 张艳[2] 徐德忠[1] 王安辉[1] 张磊[1] 孙长生[1] 李良寿[1] 

机构地区：[1]第四军医大学预防医学系流行病学教研室,西安710032 [2]陕西省血液中心

出　　处：《中华流行病学杂志》2004年第9期775-778,共4页Chinese Journal of Epidemiology

摘　　要：目的 探讨吸烟、饮酒与食管癌p53基因改变之间的关系。方法 应用Meta分析对有关研究吸烟、饮酒与食管癌p53基因改变的文献进行综合评价。结果 纳入Meta分析的14篇研究吸烟的文献中,吸烟与P53蛋白高表达、p53基因改变(P53蛋白高表达+p53基因突变)的合并OR值分别为1.99(95％CI:1.30～3.06)、1.64(95％CI:1.13～2.37)(P<0.05),吸烟与p53基因突变的合并OR值为1.11(95％CI:0.47～2.76)(P>0.05)。11篇研究饮酒的文献中,饮酒与P53蛋白高表达、p53基因突变和p53基因改变的合并OR值分别为1.30(95％CI:0.83～2.04)、1.13(95％CI:0.67～1.90)和1.22(95％CI:0.87～1.72),合并OR值无统计学意义(P>0.05)。结论 吸烟与p53基因改变有显著联系,饮酒与p53基因改变未见显著联系。Objective To investigate the relationship between tobacco smoking,drinking and p53 alteration in esophageal carcinoma. Methods Literature on the relationship between p53 alteration in esophageal carcinoma and tobacco smoking,drinking through Meta-analysis were reviewed. Results In 14 selected papers related to tobacco smoking, pooled odds ratio (OR) of tobacco smoking with P53 overexpression and p53 alteration were 1.99(95% CI: 1.30-3.06) and 1.64(95% CI: 1.13-2.37), respectively (P< 0.05). Pooled OR of tobacco smoking with p53 mutation was 1.11 (95% CI: 0.47-2.76) (P> 0.05 ). In 11 selected papers on alcohol drinking, pooled OR of drinking with P53 overexpression,p53 mutation and p53 alteration were 1.30 (95 % CI : 0.83-2.04 ), 1.13 (95 % CI : 0.67-1.90) and 1.22(95% CI:0.87-1.72) respectively (P>0.05). Conclusion There were significant relations between tobacco smoking and p53 alteration while there were no significant relations between alcohol drinking and p53 alteration.

关 键 词：吸烟 饮酒 食管癌 P53 基因改变 

分 类 号：R735.1[医药卫生—肿瘤]