间歇性无氧运动对小鼠脑、心肌、骨骼肌抗氧化能力及脂质过氧化损伤的影响  

Effects of Interval Anaerobic Training on Antioxidant Capacity and Lipid Peroxidative Damage of Brain, Myocardium and Skeletal Muscle in Mice

作　　者：刘晓莉[1] 侯莉娟[1] 刘赟[2] 喻云梅[2] 乔德才[1] 

机构地区：[1]山西大学体育学院运动人体科学实验室,太原030006 [2]华东师范大学环境科学系生理组

出　　处：《中国运动医学杂志》2004年第4期390-394,共5页Chinese Journal of Sports Medicine

基　　金：山西省高科技开发项目;项目编号 2 0 0 3 71

摘　　要：目的 :观察间歇性无氧运动对小鼠脑、心肌、骨骼肌抗氧化能力和脂质过氧化损伤的影响。方法 :选用 96只昆明雄性小鼠 ,建立间歇无氧运动模型 ,观察运动后脑、心肌、骨骼肌SOD活性、T -AOC能力及MDA含量的变化及间歇性无氧运动对小鼠行为能力的影响。结果 :间歇运动后 ,小鼠骨骼肌SOD活性、T -AOC及MDA含量显著高于对照组 (P <0 0 5 )。心肌SOD和T -AOC变化与骨骼肌大致相同 ,显著高于对照组 (P <0 0 5 ) ,但MDA差异不显著 (P >0 0 5 )。脑组织T -AOC升高显著 (P <0 0 5 )。结果显示 :间歇运动使小鼠体重自然增长速度延缓。间歇性无氧运动对小鼠抗氧化能力及脂质过氧化水平的影响存在较明显的组织差异。Objective: To observe the effects of interval anaerobic training on antioxidant capacity and lipid peroxidative damage of brain, heart, skeletal muscle in mice. Methods: Selected 96 male Kunming mice, setting up anaerobic training model, the changes in SOD activity and T-AOC and MDA contents were measured. Results: The level of SOD activity and T-AOC and MDA contents in skeletal muscle were significant higher than controls after interval training (P<0.05).The changes in SOD and T-AOC in heart were similar to skeletal muscle(P<0.05), but there was no difference in MDA content between training group and control group(P>0.05). T-AOC in brain increased significantly (P<0.05 , P<0.01).The range of most indexes in STG and LTG remarkably related to time lasting and density enhancing (P<0.05, P<0.01, P<0.001). Conclusion: Interval training delayed natural growth of mice weight exercise capacity fall into a decline with time lasting and density enhancing. Effects of interval anaerobic training on antioxidant capacity and lipid peroxidative damage varied in different tissues.

关 键 词：间歇性无氧运动 小鼠 脑 心肌 骨骼肌 抗氧化能力 脂质过氧化损伤 氧耐力 

分 类 号：R87[医药卫生—运动医学]