正常结肠运动与血中胃泌素、生长抑素含量的初步研究  

A Preliminary study on colon transit of the normal adults and gastin and somatostatin in plasma

作　　者：曾曦[1] 焦俊[1] 唐培兰[1] 徐胜生[2] 马启玲[3] 张兰花[1] 

机构地区：[1]贵阳医学院附院核医学科,550004 [2]贵阳医学院2000级 [3]贵阳医学院中心实验室

出　　处：《贵州医药》2004年第9期774-778,共5页Guizhou Medical Journal

基　　金：贵阳市科委基金资助项目 (2 0 0 10 1 3 )

摘　　要：目的探讨结肠运动与胃泌素、生长激素的关系。方法 90例正常人 ,其中男性 5 2例 ,女性 38例 ,分青年组 34例 ,中年组 33例 ,老年 2 3例。运用结肠运输实验观察各年龄组结肠运输情况 ,采用放免法测定其餐前后血中GAS及SS的浓度。结果 (1)结肠运输试验 :青、中、老年组结肠运动力由强减弱 ,青、中年组 4 8小时内结肠运动力明显高于老年组 (P <0 0 5 )。男女组间结肠运输试验差异无显著意义 (P >0 0 5 )。 (2 )正常人空腹血清GAS、血浆SS的浓度 :分别为 5 1 0 0± 2 1 92 pg/ml、17 72± 11 6 8pg/ml,餐后血GAS、SS :分别为 10 2 15± 4 9 15 pg/ml、37 30± 30 0 7pg/ml。 (3)餐后 1小时各组血中GAS、SS浓度 ,青年组分别为 10 5 4 7± 5 6 4 2pg/ml、32 6 8± 17 2 5 pg/ml;中年组分别为 :10 4 38± 38 6 7pg/ml、33 6 5± 2 0 98pg/ml;老年组分别为 94 13± 5 1 87pg/ml、6 1 70±30 80 pg/ml;老年组餐前后血中SS与青、中年组相比差异有显著意义 (P >0 0 5 )。 (4)空腹与餐后比较 :青、中、老年组餐后GAS、SS均明显高于餐前 (P <0 0 5 )。 (5 )、2 4、4 8、72小时 80 %TT组间SS浓度递升。结论 (1)本研究结肠运输试验结果符合 72小时 80 %TT标准。 (2 )正常人血中GAS、SS :空腹分别为 5 1Objective To study the relation between colonic transit and GAS,SS. Methods 90 healthy adults, (52males, 38femals) were divided into three groups: young group (34 cases ranging from 20 to 39 years old), middle-age group (33 cases ranging from 40 to 59 years old), old-age group (26 cases including more than 60 years old). Colon transit of every group was observed by colonic transit test. The concentrations of plasma GAS and SS were observed by radioimmunoassy (RIA). Results The colon motility of young group and middle age groups were significantly stronger than that of old-age group within 48 hours (P<0.05). There was no significantly difference between male and female (P>0.05). Plasma SS of old age group significantly different than those of young group and middle age group (P<0.05). There were no significantly differences among three groups about plasma GAS level (P>0.05). There was no significantly difference between male and female (P>0.05). The level of plasma GAS, SS after meal were significantly higher than that before meal of three groups (P<0.05). Conclusions Plasma SS levels were increase higher as age increases before and after meal, plasma GAS,SS level significantly increased after meal and colon motility decreased while plasma SS levels increased.

关 键 词：结肠运动 胃泌素 生长抑素 结肠运输实验 

分 类 号：R574.62[医药卫生—消化系统]