Cx43蛋白在子宫内膜癌组织的表达及临床意义  

Expression of Connexin43 proteins in endometrial carcinoma and clinical significance

作　　者：陈卓[1] 陈晓玲[1] 

机构地区：[1]贵阳医学院附属医院妇产科,550004

出　　处：《贵州医药》2004年第9期797-799,共3页Guizhou Medical Journal

摘　　要：目的探讨细胞间隙连接蛋白在子宫内膜癌中的表达及其与子宫内膜癌浸润转移的关系。方法应用SP免疫组织化学方法 ,检测 30例子宫内膜癌组织 (内膜癌组 ) ,30例子宫内膜不典型增生组织 (不典型组 ) ,30例正常增生期子宫内膜组织 (正常组 )中的Cx4 3蛋白的表达。结果 (1)Cx4 3蛋白在正常组、不典型组及内膜癌组的表达阳性率分别为 80 %、5 3.3%及 4 6 .7% ;正常组与不典型组和内膜癌组比较 ,差异有显著意义 (P <0 .0 5 )。 (2 )Cx4 3蛋白在病理分级为G1的内膜癌中的阳性率为 80 % ,高于G2 (6 0 .0 % )、G3 者 (10 .0 % ,P <0 .0 5 )。 (3)浅肌层浸润的内膜癌阳性率为5 9 .1% ,高于深肌层浸润者 (12 .5 % ,P <0 .0 5 )。 (4)手术分期为Ⅰ～Ⅱ期的内膜癌阳性率为 5 4 .2 % ,Ⅲ～IV期者的阳性率分别为 16 .7% ;两者比较差异无显著意义 (P >0 .0 5 )。结论Cx4 3蛋白与内膜癌发生发展有关 ,可作为诊断、了解病变程度和监测预后的重要指标之一。Objective To investigated the expression of connexin43 proteins in human endometrial carcinoma tissue. Methods The changes in the expression of the gap junction proteins-connexin43 (Cx43) in human normal endometrium、atypical hyperlasias and endometrial cancer samples were determined by immunohistochemistry. Results (1)The detection rates of Cx43 protein were 80.0%, 53.3% and 46.7% respectively in normal endometrium tissues, atypical hyperlasias tissues, and endometrial cancer tissues. (2) The positive expression of Cx43 proteins in grade I carcinoma cells were 80.0%, grade II 60.0% and grade III 10%. (3) The positive rate of the endometrial carcinoma with light layer invasion was higher (59.1%) than deep layer invasion (12.5%). (4) The detection rates in stage I～II and III～IV carcinoma cells were 54.2%, and 16.7% respectively. Cx43 proteins expression was significantly associated with pathological grade and depth of myometrial invasion (P<0.05), but irrelevant with stage.Conclusion The expression of Cx43 proteins may play an important role in the carinogenesis of endometrial cancers.

关 键 词：CX43蛋白 子宫内膜癌 基因表达 肿瘤 

分 类 号：R737.33[医药卫生—肿瘤]