胶质瘤伽玛刀治疗的初步结果  

Gamma knife radiosurgery in the treatment of glial tumors: preliminary results

作　　者：王恩敏[1] 周良辅[1] 潘力[1] 王滨江[1] 王晨[1] 袁士毅[2,3] 徐伟民[2,3] 张斌[2,3] 蔡佩武[2,3] 戴嘉中[2,3] 

机构地区：[1]上海伽玛刀医院,上海华山医院神经外科,上海200233 [2]上海伽玛刀医院 [3]上海华山医院神经外科,上海200233

出　　处：《微侵袭神经外科杂志》1996年第1期25-27,共3页

摘　　要：本文报告应用γ-刀治疗48例经手术治疗、术后放疗和（或）化疗后复发的胶质瘤。其中男30例、女18例,年龄平均38岁（7～74）岁。肿瘤最大直径11.3～69.8 mm,平均35mm。最大中心照射剂量22～55Gy,平均32Gy。肿瘤周边剂量11～20Gy,平均15Gy.照射的等中心点数1～15个,平均7个。随访40例,随访率83.3％,随访时间9～22个月,平均14个月。至最后一次随访时,死亡16例,3例症状好转,9例病情无加重。40例的存活时间;2～22个月,平均10.9个月。肿瘤直径小治疗效果好,而肿瘤直径大疗效不佳。In the period between October 1993 and December 1994, 48 patients (30 males and 18 females)who had recurrent glioma after surgical resection, radiation therapy and/or chemotherapy, were treated with gamma knife ra-diosurgery with a mean follow-up time of 14. 9 months. The patient's age ranged from 7 to 74 years (mean 38 years ) and Karnofsky performance score of the patients was 60%-90% (mean 80%). The tumors had a mean maximum diameter of 35 mm (11-69 mm) and most lesions required multiple-shot dose plans, with an average of 7 shots per patient (range 1-15 shots). The mean close administered to tumor center and margin was 32. 4 Gy (22 -55 Gy) and 15. 1 Gy(11-20Gy)respectively with 30% -60% isodose line to the tumor margin. Forty patients underwent follow-up from 9 to 22 months. At last follow-up, there were 16 patients dead, three patients with postoperative imaging decreased in tumor sizes and improved in neurological deficits, nine remained neurological stable. The mean survival period period in this series was 10. 9months (range 2-22 months). The preliminary results showed that the patients with smaller lesions had comparably longer survival than the patients with larger lesions.

关 键 词：胶质瘤 伽玛刀 治疗 照射剂量 

分 类 号：R730.264[医药卫生—肿瘤]