冲顶式上颌窦提升植骨牙种植动物模型的建立  

An Experimental Model for Maxillary Sinus Elevation and Bone Grafting with Simultaneous Implant Placement with Osteotome Technique

作　　者：陈松龄[1] 黄代营[1] 周苗[1] 庾晓伟[2] 张继斌[1] 

机构地区：[1]中山大学附属第一医院口腔科 [2]中山大学附属第二医院口腔科广东广州510120

出　　处：《中山大学学报（医学科学版）》2004年第6期549-553,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省科技厅科研基金资助项目(2002B11702)

摘　　要：【目的】建立冲顶式上颌窦提升植骨牙种植的动物模型,以供上颌窦提升植骨牙种植的深入研究。【方法】拔除16只狗双侧上颌第一、第二磨牙,行冲顶式上颌窦提升,提升高度为2mm、4mm,一侧植骨,一侧不植骨,分别于术后3周、6周、12周、24周处死动物各4只,标本都经大体观察、放射检查及组织学检查。【结果】移植骨愈合良好,种植体牢固,窦底黏膜完整。上颌窦提升2mm时,种植体顶端可见骨质存在;提升4mm时,只见窦黏膜,不见新骨。上颌窦提升同期植骨并植入种植体,可见种植体顶端有新骨形成,覆盖种植体。【结论】狗有理想的上颌窦提升解剖条件,窦底提升术时可将窦底黏膜提升并保持完整,移植骨能形成新骨与牙种植体形成骨性结合,可作为研究上颌窦提升植骨同期牙种植动物模型。ObjectiveTo establish an animal model for maxillary sinus elevation and bone grafting with simultaneous implantation with osteotome. MethodsThe first and second molars of 16 dog's maxilla were extracted and sinus floor were elevated. The heights of elevation were 2 mm and 4 mm. One side was grafted with autogenous bone and the other side was not grafted. After 3, 6, 12, and 24 weeks, 4 dogs were sacrificed at the same time. The samples were evaluated by general observation, radiographic observation, and histology examination. ResultsGrafted bone integrated with “base bone', the implants got stable, and the sinus membrane remained intact. When sinus elevation achieved 2 mm height, the bone was formed on the top of the implants. When sinus elevation achieved 4 mm height, no bone was formed on the top of implant. All grafted bone formed new bone and osteogenesis of autografted bone was observed at the top of implants. ConclusionDog has ideal anatomic conditions for maxillary sinus elevation. Membrane remains intact after elevation and grafted bone is integrated with implants. Dog can be used as animal model for maxillary sinus elevation with simultaneous bone graft and implant placement.

关 键 词：上颌窦提升 移植骨 牙种植 种植体 动物模型 黏膜 双侧 条件 保持 目的 

分 类 号：R783.6[医药卫生—口腔医学] R782[医药卫生—临床医学]