nm23H1和血管内皮生长因子的表达与大肠癌浸润和转移的关系  

The Study of the Relationship between the Expressions of Nm23H1 and VEGF and the Ability of the Invasion and Metastasis in Colorectal Cancer

作　　者：唐朝晖[1] 刘庆国[2] 江拥军[1] 齐海智[3] 

机构地区：[1]湖南省永州市人民医院肿瘤科,425006 [2]湖南省永州市职业技术学院,425006 [3]湖南省中南大学湘雅二医院,410008

出　　处：《中国误诊学杂志》2004年第9期1386-1387,共2页Chinese Journal of Misdiagnostics

摘　　要：目的 :探讨 nm2 3H1和 VEGF的表达与大肠癌浸润和转移的关系。方法 :采用免疫组织化学 SP法 ,显示nm2 3H1和 VEGF的表达与大肠癌浸润和转移的相关性。结果 :nm2 3H1的表达与大肠癌的浸润深度 ,及淋巴结转移 (P<0 .0 5 )有关 ,VEGF的表达与大肠癌的浸润深度、肿块大小、肿块的部位及淋巴结转移状况有关 (P<0 .0 5 ) ,二者均是独立的预后因素。结论 :大肠癌组织中 nm2 3H1及 VEGF的表达是判断大肠癌患者预后的有效指标。Objective:To study the expressions of nm23H1 and VEGF in colorecta l cancer and their relationship with the ability of invasion and metastasis .Methods:Immunohistochemical SP method was used to detect the expressions of nm23H1 and VEGF in 64 cases paraffin tissues.Results:The expression of nm23H1 was correlated with i nvasion and lymph metastasis(P<0.05).Conclusion:The expres sion of nm23H1 and VEGF could sreve as prognostic predictors.

关 键 词：结直肠肿瘤/病理学 肿瘤浸润 肿瘤转移 转录因子/生物合成 血管内皮生长因子A/生物合成 

分 类 号：R735.340[医药卫生—肿瘤]