尼莫地平改善急性脑梗塞脑缺血缺氧的临床研究  

Clinical study of nimodipine improving ischemia and anoxemia of acute cerebral infaction

作　　者：曹启富[1] 刘军[1] 仇长利[1] 

机构地区：[1]卫生部中日友好医院心肾科,北京100029

出　　处：《中国现代医药杂志》2004年第5期15-16,共2页Modern Medicine Journal of China

摘　　要：目的观察尼莫地平改善急性脑梗塞脑缺血缺氧的作用机制。方法将80例经CT确诊的急性脑梗塞患者随机分为2组,治疗组(40例)静滴尼莫地平,对照组(40例)静滴胞二磷胆碱,疗程均为2周。结果治疗1～2周后两组神经功能缺损程度评分的平均减少值(MDSND)均增加,治疗组增加更明显(P<0.05)。治疗组的总有效率明显高于对照组(P<0.05),治疗组能够使脑内氧合血红蛋白(HbO2)和氧饱合度(SaO2)增加,同对照组比较有显著性差异(P<0.05)。结论尼莫地平对急性脑梗塞患者神经功能缺损的恢复疗效肯定,在扩张脑血管及增加脑血流量、改善急性脑梗塞患者脑缺血缺氧方面,综合疗效较胞二磷胆碱更好。Objective To study the mechanism of nimodipine improving ischemia and anoxemia of acute cerebral infarction(ACI). Methods 80 patients with ACI were divided into nimodipine group (40 subjects),nicholin group (40 subjecsts ) randomly. In treatment group, the patients were given nimodipine, by dropping in vein. In control group, the patients were given nicholin. Results After treatment for 1 or 2 weeks, MDSND increased in 2 groups, and comparison was significant(P<0.05). The total therapeutic effectiveness of treatment group was increased, and comparison was significant(P<0.05). The cerebral HbO2 and SaO2 of treatment group were increased, and comparison was significant (P<0.05). Conclusion Nimodipine has a good therapeutic effectiveness in the treatment of acute cerebral infarction ,it coud recover the degree of nervus founction. It is better than nicholin in general effectiveness, expanding cerebrovascular, increasing cerebral blood flow, improvement of cerebral ischemia and anoxia of ACI.

关 键 词：尼莫地平 急性脑梗塞 脑缺血缺氧 胞二磷胆碱 氧饱合度 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R971[医药卫生—临床医学]