核受体LXRa靶基因研究进展  

The Research Development of Nuclear Receptor LXRa

作　　者：刘伟治[1] 叶飞[1] 岳莉多[1] 余长缨[1] 沈建华[1] 蒋华良[1] 沈旭[1] 

机构地区：[1]中国科学院上海药物研究所药物发现与设计中心,上海201203

出　　处：《世界科技研究与发展》2003年第6期51-54,共4页World Sci-Tech R&D

摘　　要：核受体的研究近几年已有飞速的发展。LXRa(Liver X Receptor a)是一种与脂类代谢有关的核受体。研究发现LXRa的靶基因具有调节脂类的吸收、运输、转化和生物合成的功能,此外,LXRa在糖类的代谢等方面也有重要的调控作用。研究结果表明LXRa与动脉粥样硬化的发生有非常密切的关系。目前利用LXRa为靶标进行抗动脉粥样硬化药物筛选已经成为一个重要的研究方法。In recent years, the research in nuclear receptors has been developed rapidly. LXRa, which belongs to a subgroup of nuclear receptors , is considered to play an important role in the regulation of lipid metabolism. It has been found that LXRa target genes have the ability in regulating the assimilation , transportation , transformation , and biosynthesis of lipids. In addition , LXRa also takes part in the regulation of glucose metabolism . To date, it has been confirmed that the exploration of anti-atherogenic pharmacological agents using LXRa as target is a promising research project.

关 键 词：核受体 靶基因 LXRΑ 动脉粥样硬化 胆固醇 药物设计 抗动脉粥样硬化药 

分 类 号：R543[医药卫生—心血管疾病]