新化合物哌芳安他对兔和鹌鹑高脂血症性脂肪肝的影响  

Effects of the novel compound pivanampeta on the fatty liver with hyperlipidemia in rabbits and quails

作　　者：王倩[1] 汪海[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《中国药理学通报》2003年第12期1349-1353,共5页Chinese Pharmacological Bulletin

基　　金：国家重点基础研究发展规划项目资助课题GT1 9980 51 1 1 2;赛德维康医药研究院新药研究基金资助课题No 1 9990 0 1

摘　　要：目的　观察新化合物哌芳安他对兔和鹌鹑高脂血症脂肪肝的影响。方法　① 2 4只♂兔随机分为正常饮食组、高脂模型组、哌芳安他 1和 5mg·kg- 1组。高脂饲养 12wk后 ,测定血清TC水平。取动物肝脏 ,进行病理学检查 ,并测定肝组织匀浆中TC、MDA的含量和GSH Px的活性。②181只♂鹌鹑随机分为正常饮食组、高脂模型组、辛伐他汀(simvastatin) 5mg·kg- 1组、哌芳安他 3 ,6和 9mg·kg- 1组。鹌鹑在高脂饲养 11wk时 ,测定血清TC水平。 14wk时 ,处死鹌鹑 ,取肝脏 ,进行病理学检查 ;18wk时 ,处死剩余鹌鹑 ,测定肝系数。结果　哌芳安他可减轻高脂饮食引起的兔和鹌鹑的肝脏脂肪变性 ,降低兔肝组织中的胆固醇水平和升高GSH Px的活性 ,抑制兔和鹌鹑肝系数的升高。AIM To investigate the effects of the novel compound pivanampeta on the fatty liver induced by cholesterol-feeding in rabbits and quails. METHODS ①24 male rabbits were divided into four groups randomly as following: control group, model group, pivanampet 1 and 5 mg·kg -1 groups. The serum levels of total cholesterol were determined after the rabbits were cholesterol-fed for 12 weeks. The morphological changes of liver were observed. The levels of cholesterol and malonal-dialdehyde and the activities of glutatione peroxidase in the homogenate of liver were also measured.②181 male quails were divided into six groups randomly:control group, model group, Simvastatin 5 mg·kg -1 group, pivanampet 3,6 and 9 mg·kg -1 groups. The serum levels of total cholesterol were determined after the quails had been fed with cholesterol diets for 11 weeks. After 14 weeks part of the animals were killed, the morphological changes of liver were observed. The hepatic coefficient were determined after the remaining quails were cholesterol-feeding for 18 weeks. RESULTS Pivanampet alleviated the liver Steatosis induced by cholesterol-feeding in rabbits and quals. It decreased total cholesterol levels, elevated the activity of glutatione peroxidase in the rabbits liver, and reversed the increasing hepatic coefficient in rabbits and quails. CONCLISION The novel compound Pivanampet can delay the formation of fatty liver by cholesterol-feeding.

关 键 词：高血脂症 脂肪肝 抗氧化 

分 类 号：R-332[医药卫生]