杂种家兔贫血模型的建立  

Establishment of the Anemic Model with Hybrid Rabbits

作　　者：张圣明[1,2,3] 黄冠文 张伟栋[1,2,3] 李锋杰[1,2,3] 李如江[1,2,3] 张艳玲[1,2,3] 刘向东 

机构地区：[1]山东省潍坊医学院基础部 [2]潍坊市药品检验所 [3]潍坊市人民医院放疗科

出　　处：《中国实验动物学报》1999年第1期43-46,共4页Acta Laboratorium Animalis Scientia Sinica

摘　　要：目的为建立溶血性贫血（ＨＡ）和再生障碍性贫血（ＡＡ）两种贫血动物模型，研究ＨＡ和ＡＡ的发病机理。方法５０只杂种健康家兔随机分为两组，２５只皮下注射盐酸苯肼制备溶血性贫血（ＨＡ）模型；另２５只行６０Ｃｏγ－射线亚致死量全身照射后输注同种异体胸腺淋巴细胞诱发ＡＡ型。结果ＨＡ组成功率１００％，死亡率５６％（１４／２５只）；ＡＡ组成功率为９２％（２３／２５只）。结论两种模型的发生时间较稳定，实验重复性好，结果可靠。bjective: To study the pathogenic mechanism of hemolytic anemia(HA) and aplastic anemia(AA), models of hybrid rabbits with HA and AA were establish. Methods: 50 hybrid rabbits were divied at random into two groups, 25 rabbits were injected with phenyl hydrochloride subcutaneous to prepare the model of HA. The other 25 rabbits, the AA group were given the xenogenic thymus lymphocytes transfusion on general irradiation by 60 Co γ-ray of half lethal dose. Results: The rate of success was 100% and death in 14 out of 25(56%) rabbits in group HA. In group AA the rate of success was 92% in 23 out of 25 rabbits. Conclusions: The two anemic models have a stabilization in pathogenenic period, good experimental repetition and the reliable results, and they will lay a foundation on HA and AA the pathogenesis and the experimental study.

关 键 词：HA AA 溶血性贫血 发病机理 成功率 全身照射 家兔 杂种 致死量 发生时间 

分 类 号：Q754[生物学—分子生物学] R556.5[医药卫生—血液循环系统疾病]