A New Method of Separation of Four Benzodiazepines by RP-CEC  

作　　者：JinLanZHANG TongHuiZHOU 

机构地区：[1]InstituteofMateriaMedica,ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Beijing100050

出　　处：《Chinese Chemical Letters》2004年第8期935-938,共4页中国化学快报（英文版）

摘　　要：A new method to separate diazepam, nitrazepam, estazolam, alprazolam was established on both C18 and C8 CEC columns. The influence of separation voltage, Tris concentration, column temperature and the percentage of acetonitrile on the resolution and retention behavior of four benzodiazepines was investigated. The results showed that the percentage of acetonitrile had the largest effect on the resolution and retention behavior of the four benzodiazepines. Other separation conditions had also effects on the resolution and retention behavior, but smaller than the concentration of acetonitrile. Optimum separation conditions were obtained to separate four benzodiazepines on C18 and C8 CEC columns.

关 键 词：Capillary electrochromatography DIAZEPAM NITRAZEPAM ESTAZOLAM alprazolam. 

分 类 号：O626[理学—有机化学] O657.7[理学—化学]