DIAZEPAM

作品数：29被引量：44H指数：4
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相关领域：医药卫生更多>>
相关作者：邓晓军郭德华朱坚李波王存国更多>>
相关机构：上海出入境检验检疫局上海市兽药饲料监察所中国刑警学院河南医科大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Pharmacology & Pharmacy》《Journal of Chinese Pharmaceutical Sciences》更多>>
相关基金：国家自然科学基金更多>>
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Small-molecule caspase-1 inhibitor CZL80 terminates refractory status epilepticus via inhibition of glutamatergic transmission
《Acta Pharmacologica Sinica》2024年第7期1381-1392,共12页Fei Wang Yu Wang Qing-yang Zhang Ke-yu Hu Ying-jie Song Lin Yang Fan Fei Ceng-lin Xu Sun-liang Cui Ye-ping Ruan Yi Wang Zhong Chen 
supported by grants from the National Natural Science Foundation of China (82330116 and 82022071);the Natural Science Foundation of Zhejiang Province (LD22H310003).
Status epilepticus(SE),a serious and often life-threatening medical emergency,is characterized by abnormally prolonged seizures.It is not effectively managed by present first-line anti-seizure medications and could re...
关键词：status epilepticus DIAZEPAM caspase-1 inhibitor therapeutic time window glutamatergic synaptic transmission 
A Preliminary Gas Chromatography‑Mass Spectrometry‑Based Metabolomics Study of Rats Ingested Diazepam or Clonazepam
《Journal of Forensic Science and Medicine》2020年第4期117-125,共9页Shiyong Fang Jianxia Chen Xinhua Dai Yuzi Zheng Hao Wu Yingqiang Fu Jian Li Yi Ye Linchuan Liao 
The study was financially supported by the Project of the National Natural Sciences Foundation of China(81373239);The Innovation and Business Starting-oriented training program of College Students in Sichuan Province(C2020113713).
Drug-facilitated sexual assault(DFSA)is a sexual act in which the victim is unable to give or rescind consent due to alcohol or drug intoxication,which involved the abuse of benzodiazepines around the world.Convention...
关键词：CLONAZEPAM DIAZEPAM gas chromatography-mass spectrometry liquid chromatography-tandem mass spectrometry metabolomics 
Diazepam reduces synaptic GABA type areceptor availability via multiple trafficking mechanisms
《中国药理学与毒理学杂志》2017年第10期952-952,共1页Joshua M LORENZ-GUERTIN Sabyasachi DAS Tija C JACOB 
supported by National Institute of Health(T32GM008424);Whitehall Foundation;William C DEGROAT Neuropharmacology Departmental Fellowship;Pharmacology and Chemical Biology Startup Funds
OBJECTIVE Investigate the effects of diazepam(DZP) on γ2 subunit containing GABA type A receptor(GABA A R) trafficking.METHODS Immunofluorescence microscopy measured surface GABA A Rs and gephyrin in rat cortical neu...
关键词：GABA type A receptor GEPHYRIN TRAFFICKING DIAZEPAM 
Role of Routine Benzodiazepin in Eliciting Classical Electroencephalogram (EEG) Response in Suspected Sub-Acute Sclerosing Panencephalitis (SSPE) Cases
《World Journal of Neuroscience》2017年第1期32-37,共6页Yamin Shahriar Chowdhury Narayan Chandra Saha M. Abdullah Yusuf Ariful Islam S. K. Azimul Hoque Rajib Nayan Chowdhury M. Enayet Hussain 
Background: EEG could be normal or atypical in spite of suggestive clinical features and positive measles Ab of SSPE cases which could have typical EEG pattern after Benzodiazepine. Objectives: The purpose of the pres...
关键词：Sub-Acute SCLEROSING Panencephalitis (SSPE) EEG DIAZEPAM Midazolam 
Effects of oral premedication on cognitive status of elderly patients undergoing cardiac catheterization被引量：1
《Journal of Geriatric Cardiology》2015年第3期257-262,共6页Javed M Ashraf Marc Schweigel Neelima Vallurupalli Sandra Bellantonio James R Cook 
Background Sedatives and analgesics are often administered to achieve conscious sedation for diagnostic and therapeutic procedures. Appropriate concerns have been raised regarding post procedure delirium related to pe...
关键词：Cardiac catheterization DIPHENHYDRAMINE DIAZEPAM DELIRIUM The elderly 
Effects of diazepam on glutamatergic synaptic transmission in the hippocampal CA1 area of rats with traumatic brain injury被引量：1
《Neural Regeneration Research》2014年第21期1897-1901,共5页Lei Cao Xiaohua Bie Su Huo Jubao Du Lin Liu Weiqun Song 
supported by the National Natural Science Foundation of China,No.81201984;the Scientific Research Project of Shaanxi Provincial Health Department in China,No.2010E03;the Yulin Municipal Science and Technology Research and Development Project,No.Sf12-06
The activity of the Schaffer collaterals of hippocampal CA3 neurons and hippocampal CA1 neurons has been shown to increase after lfuid percussion injury. Diazepam can inhibit the hy-perexcitability of rat hippocampal ...
关键词：nerve regeneration traumatic brain injury fluid percussion injury excitatory synaptic transmission hippocampal CA1 pyramidal neurons paired-pulse facilitation miniature excitatory postsynaptic potential gamma-aminobutyric acid post-traumatic hyperactivity intracellular recording NSFC grant neural regeneration 
A Study of the Effect of <i>Citrus aurantium</i>L. Essential Oil on Anxiety and Its Interaction with GABAergic Pathways in Male Mice
《Journal of Behavioral and Brain Science》2014年第10期470-476,共7页Maryam Khosravi Shahrzad Khakpour Leila Adibi Mahsa Hadipour Jahromy 
Anxiety is among the most common disorders affecting a great number of people. Different neurotransmitter systems, such as GABAergic system, play an important role in emergence of anxiety-related behaviors. In this st...
关键词：ANXIETY Mice CITRUS aurantium L. DIAZEPAM 
Acetazolamide attenuates chemical-stimulated but not thermal-stimulated acute pain in mice
《Acta Pharmacologica Sinica》2014年第1期41-47,共7页Ya-jie SUN Ying CHEN Chong PANG Ning WU Jin LI 
Acknowledgements This work was supported by the National Natural Science Foundation of China （Grant No 81171046）.
Aim： Acetazolamide （AZA）, a carbonic anhydrase （CA） inhibitor, has been found to alleviate inflammatory and neuropathic pain in rats. In the present study, we investigated the effects of AZA on thermal- and chem...
关键词：ACETAZOLAMIDE methazolamide DIAZEPAM ANALGESIA tail-flick test hot-plate test capsaicin test formalin test acetic acid- induced writhing test carbonic anhydrase GABAA receptor 
Melatonin and Diazepam Affect Anxiety-Like and Depression-Like Behavior in Wistar Rats: Possible Interaction with Central GABA Neurotransmission
《Journal of Behavioral and Brain Science》2013年第7期522-533,共12页Sihame Ouakki Fatima Zahra El Mrabet Ibtissam Lagbouri Aboubaker El Hessni Abdelhalem Mesfioui Paul Pévet Etienne Challet Ali Ouichou 
Recent studies have shown the importance of the GABA-ergic transmission in the pathophysiology of anxiety and depressive disorders in humans. Our present study aims to investigate the interaction of melatonin (MEL) wi...
关键词：MELATONIN DIAZEPAM Depression ANXIETY Open Field Elevated plus MAZE Forced SWIMMING Test Rat 
A Rank-Order Procedure Applied to an Ethoexperimental Behavior Model—The Multivariate Concentric Square Field<sup>TM </sup>(MCSF) Test
《Journal of Behavioral and Brain Science》2013年第4期350-361,共12页Bengt J. Meyerson Betty Jurek Erika Roman 
Designing relevant animal models in order to investigate the neurobiological basis for human mental disorders is an important challenge. The need for new tests to be developed and traditional tests to be improved has ...
关键词：Trend ANALYSIS DIAZEPAM Elevated Plus MAZE MULTIVARIATE Data ANALYSIS 
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