药物诱发三叉神经痛觉敏感征的实验研究  

EXPERIMENTAL STUDY OF THE PATHOGENY OF TRIGEMINAL NEURALGIA THROUGH DRUG-EVOKING HYPER-IRRITABILITY

作　　者：张冰[1] 李晓刚[1] 郭福林[1] 高瑞驹[1] 尹晓东[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院口腔颌面外科,哈尔滨150001

出　　处：《中国疼痛医学杂志》2004年第4期200-202,共3页Chinese Journal of Pain Medicine

摘　　要：目的 :通过对苦毒素和马钱子碱引起三叉神经痛样刺激过敏征进行分析 ,探讨三叉神经痛的发病机制。方法 :在大鼠脊髓表面使用此两种药物 ,引发后肢搔抓运动。记录胫前肌肌电图 (elec tromyogram ,EMG)并进行测量。通过对同只大鼠左右两侧对比 ,来分析它们在诱发疼痛中的作用。结果 :在麻醉和清醒状态下 ,两药物引起的EMG振幅差别有统计学意义 (P <0 .0 0 1)。其中在麻醉状态下 ,马钱子碱引起的EMG振幅大于苦毒素 ;清醒状态下 ,苦毒素引起的EMG大于马钱子碱。结论 :三叉神经痛可能与GABA抑制系统异常有关。Objective:We compared hyper irritability resulting from picrotoxin and strychnine to analyze the mechanism of trigeminal neuralgia. Methods: These drugs were separately applied onto the surface of the medulla, causing the rat to scratch the ipsilateral face with hindlimb.The eletromyogram(EMG) of the anterior tibial muscle was recorded. Results: When rats were anesthetized, the amplitude of EMG of the side of strychnine application was higher than that of picrotoxin. Whereas the rats were awaked, the result was reversed. Conclusion: The trigeminal neuralgia might be resulted from the abnormality of the GABA inhibition system.

关 键 词：三叉神经痛觉敏感征 实验 苦毒素 马钱子碱 发病机制 

分 类 号：R745[医药卫生—神经病学与精神病学]