罗库溴铵用于胆汁淤积病人的临床效应
e analysis of clinical effect of rocuronium bromide in pantients with cholestasis</em>
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<p class='author'><strong>作 者：</strong><a href='/writer/article.aspx?id=100000009567461' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e7%ab%a5%e8%89%b3%e6%a2%85%5d' title='童艳梅[1]'>童艳梅[1]</a> <a href='/writer/article.aspx?id=100000005022829' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e7%8e%8b%e6%b0%b8%e5%85%89%5d' title='王永光[2]'>王永光[2]</a> <em> </em></p><p class='organ'><strong>机构地区：</strong><a href='/organ/article.aspx?id=838241&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e5%8d%97%e4%ba%ac%e7%90%86%e5%b7%a5%e5%a4%a7%e5%ad%a6%e5%8c%bb%e9%99%a2' title='[1]南京理工大学医院,江苏省南京市210094'>[1]南京理工大学医院,江苏省南京市210094</a> <a href='/organ/article.aspx?id=661492&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e5%8d%97%e4%ba%ac%e9%87%91%e9%99%b5%e5%8c%bb%e9%99%a2%e9%ba%bb%e9%86%89%e7%a7%91' title='[2]南京金陵医院麻醉科,江苏省南京市210002'>[2]南京金陵医院麻醉科,江苏省南京市210002</a> <em> </em></p><p class='from'><strong>出 处：</strong><a href='/journal/summary.aspx?gch=98000X' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=J%3d%5b%e4%b8%ad%e5%9b%bd%e5%8e%82%e7%9f%bf%e5%8c%bb%e5%ad%a6%5d' title='中国厂矿医学'>《中国厂矿医学》</a>2004年第4期270-272,共3页<em>Chinese Medicine of Factory and Mine</em></p><p class='abstrack'><strong>摘 要：</strong>目的 观察罗库溴铵用于胆汁淤积病人的临床药效特点。方法 选择择期腹腔内手术病人30例,其中肝、胆管结石阻塞性黄疸病人10例(A组),肝、胆管结石无黄疽病人10例(B组),无肝胆疾患病人10例(对照组C组)。用神经肌肉传递功能监测仪(NMT监测仪-Datex-Ohmeda)持续监测拇内收肌颤搐,观察全静脉麻醉下罗库溴铵起效时间、最大抑制程度、首次诱导剂量的临床作用时间、重复追加维持剂量的临床作用时间及术毕自主恢复指数。结果 首次诱导剂量后临床作用时间三组间比较均无显著性差异。重复追加维持剂量罗库溴铵后A组临床作用时间呈逐渐延长趋势.以重复追加4次以上更为显著(P<0.05)。第6次追加剂量的临床作用时间约为第1次的两倍,达(42.7±19.4)min。B组重复追加剂量后临床作用时间亦有逐渐延长趋势。对照组6次追加剂量的临床作用时问无明显变化。术毕自主恢复指数A组及B组分别为(47.7±15.4)min、(44.1±11.4)min,与对照组相比均有统计学意义(P<0.05)。结论 罗库溴铵用于阻塞性黄疸病人主要表现为长时间反复用药有蓄积作用;无肝功能损害的胆汁淤积病人反复用药也有蓄积的趋势和自主恢复时间延长。<em><abstract>jective To observe the pharmacodynamic characteristics of rocuronium bromide in patients with cholestasis. Methods 30 patients undergoing abdominal operation were divided into 3 groups(n=10) :A( obstructive jaundice) ,B(with cholestasis but no jaundice), and C (control group ). Rocuronium 0. 6mg/kg was given to all of the patients and the time of onset, T1 maximum depression, the clinical duration of initial dose, the clinical duration of repeated administration and the recovery index were observed. Results The clinical duration of the initial dose was same in all groups, and the clinical durations of repeated maintenance doses in A group was prolonged progressively and were markedly prolonged after more than four times(P <0.05);the recovery index in A and B groups were(47. 7±15.4) min and(44. 1±11. 4)min respectively,they were delayed significantly than those in group C(P <0.05). Conclusion Rocuronium was given to patients with cholestasis might result in a longer duration of action and recovery index.</em></p><p class='subject'><strong>关 键 词：</strong><a href='/subject/article.aspx?id=4573064' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e7%bd%97%e5%ba%93%e6%ba%b4%e9%93%b5%5d' title='罗库溴铵'>罗库溴铵</a> <a href='/subject/article.aspx?id=874278' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e8%8d%af%e6%95%88%e5%ad%a6%5d' title='药效学'>药效学</a> <a href='/subject/article.aspx?id=74342' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e8%83%86%e6%b1%81%e6%b7%a4%e7%a7%af%5d' title='胆汁淤积'>胆汁淤积</a> <a href='/zk/search.aspx?key=K%3d%5b%e8%83%86%e7%ae%a1%e7%bb%93%e7%9f%b3%e9%98%bb%e5%a1%9e%e6%80%a7%e9%bb%84%e7%96%b8%5d' title='胆管结石阻塞性黄疸'>胆管结石阻塞性黄疸</a> </p><p class='class'><strong>分 类 号：</strong><a href='/zk/search.aspx?key=C%3dR575' title='R575'>R575</a>[<a href = '/domain/article.aspx?id=493' >医药卫生—消化系统</a>] </p>
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