罂粟碱开放血脑屏障与卡氮芥治疗恶性胶质瘤的研究  

THE EFFECT OF INTRACAROT1D INFUSION OF PAPARERINE ON BRAIN - BLOOD -BERR1ER AND ITS APPLICATION TO THE TREATMENT OF MALIGNANT GLIOMA WITH BIS-CHLORONITROSOUREA

作　　者：薛洪利[1] 王翚[1] 孔令权[1] 董宝印 冯艳华 

机构地区：[1]沈阳军区总医院,110015

出　　处：《解放军医学杂志》1993年第5期363-366,共4页Medical Journal of Chinese People's Liberation Army

摘　　要：本文报告了1988年9月～1991年4月,对12例胶质瘤病人测定瘤内氨甲喋呤(MTX)含量,并经颈动脉穿刺注入罂粟碱开放血脑屏障及卡氮芥(BCNU)治疗恶性胶质瘤31例的临床研究。在12例胶质瘤病人中,经颈动脉注入罂粟碱可逆性开放血脑屏障后注入MTX,瘤内MTX含量增高,为1854±51ng/g瘤;颈动脉单纯注入MTX后为1020±51.28ng/g瘤;静脉注入MTX后瘤内含量为174±31.5ng/g瘤。31例中胶质母细胞21例,间变性星形细胞瘤10例,平均治疗2.1次,每次注入卡氮芥250mg。平均生存期101.6±32.7周,中位生存期104周。作者认为本疗法简便、安全、有效、并发症少,能延长病人生存期。The intra-tumor MTX concentration was measured in 12 patients with cerebral gliomas and 31 patients of malignant gliomas were treated with intracarotid infusion of papaverine and bis-chloroaitrosourea (BCNU). After intracarotid infusion of papaverine to open up the blood-brain-barrier (BBB), the MTX concentration within tumor tissues was 1854± 512ng/gram, which higher than that without papaverine infusion, which was 1020± 512ng/gram. The diagnosis was glioblastoma in 21 patients and anaplastic astrocytoma in 10. They received the infusion for a mean of 2.1 times with 250mg BCNU each. The mean survival time was 101.6± 32.7 weeks, with 104 weeks of median survival time. Fourteen were still living, including 11 glioblastoma and 3 anaplastic astrocytoma. Of those, four have lived over three years. We considered combination of papaverine and BCNU infusion for chemotherapy of malignant cerebral glioma is simple, safe and effective, so long as tumors were susceptible to the chemotherapeutic drugs.

关 键 词：神经胶质瘤 血脑屏障 罂粟碱 

分 类 号：R730.264[医药卫生—肿瘤]