Total Synthesis of Tetrahydroquinoline Alkaloid (+)-Angustureine  

作　　者：林宪峰 李瑜 马大为 

机构地区：[1]Department of Chemistry, Lanzhou University, Lanzhou 730000, China State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China [2]Department of Chemistry, Lanzhou University, Lanzhou 730000, China [3]State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2004年第9期932-934,共3页中国化学（英文版）

基　　金：the National Natural Science Foundation of China (Nos. 20321202,20132030).

摘　　要：(+)-(S)-Angustureine was synthesized using a CuI-catalyzed coupling reaction of iodobenzene with an enan-tiopure -amino ester as the key step. The overall yield is 36% in 7 linear steps.(+)-(S)-Angustureine was synthesized using a CuI-catalyzed coupling reaction of iodobenzene with an enan-tiopure -amino ester as the key step. The overall yield is 36% in 7 linear steps.

关 键 词：ALKALOID total synthesis COUPLING 

分 类 号：O626[理学—有机化学]