六例异性骨髓移植的细胞遗传学观察  

Cytogenetic studies on opposite sex allo-BMT for leukemias

作　　者：黄士敏[1] 曾堂清[1] 陈虎[1] 贾蜀琼[1] 

机构地区：[1]军事医学科学院附属医院

出　　处：《军事医学科学院院刊》1993年第1期43-46,共4页Bulletin of the Academy of Military Medical Sciences

摘　　要：观察了4例慢性粒细胞白血病和2例急性白血病患者移植异性供者骨髓后的染色体分带和染色体性别特征的改变结果。发现经过强烈放、化疗后的受髓者植后早期的病理性克隆细胞受到抑制;植后3个月内是植入的骨髓“扎根”的重要时机,细胞遗传学表现为嵌合状态。定期检查两性染色体核型的消长对于指导免疫抑制的应用是有益的。移植成功则逐渐呈现供者型染色体核型;若植后3个月或更长时间宿主本身染色体核型持续存在并占相当比例应警惕排斥发生。一旦移植失败常先有细胞遗传学复发,继后是临床的全面复发。Cytogenetic patterns were studied by chromosome banding technique in four casesof CML and two cases of acute leukemia after opposite sex allo-BMT with marrow from theirsiblings. The chromosome changes showed that in early stage of allo-BMT, there was a significantsuppression of pathologic cell clones. In this stage the graft was taken within the first threemonths. There might be a persistence of the 'chimera' states. The patients' marrow graduallyturned into full donor's in a successful opposite sex allo-BMT. In persistent appearance of hostchromosome in considerable percentage, one must aware of the graft rejection. In case of failure, aprodromal relapse in cytogenetics usually precede the full clinical relapse.

关 键 词：骨髓移植 染色体核型 分带技术 

分 类 号：R733.705[医药卫生—肿瘤]