抗人铁蛋白抗体-柔红霉素免疫偶联物的体内抑瘤作用  

In vivo inhibition of hepatoma growth by anti-ferritin IgG-dextran-daunomycin immunoconjugate

作　　者：陈莉[1] 李希强 陈东泉 王仁芝[1] 

机构地区：[1]军事医学科学院放射医学研究所 [2]解放军302医院

出　　处：《军事医学科学院院刊》1993年第3期199-201,共3页Bulletin of the Academy of Military Medical Sciences

摘　　要：抗人肝癌铁蛋白IgG(AHFI)与柔红霉素(Dau)通过一中间载体葡聚糖T_(40)(Dex)连接成免疫偶联物AHFI-Dex-Dau。观察了其对皮下接种人肝癌细胞Bel-7402裸鼠的体内抑瘤作用。结果表明,AHFI-Dex-Dau可大大降低柔红霉素自身的毒性,可使荷瘤鼠存活期延长,并有明显的抑制肿瘤生长的作用。Sheep anti-human ferritin IgG (AHFI) was chemically linked to daunomycin (Dau) via a mediator dextran T_(40). The antigen-binding activity of AHFI was preserved in AHFI-Dex-Dau (tested by radioimmunoassay method). The in vivo model of human hepatoma-engrafted Balb / c nude mice was established and used in the study of inhibitory effect of AHFI-Dex-Dau on tumor growth. The results showed that AHFI-Dex-Dau, compared with (1) PBS, (2) AHFI alone, (3) Dau alone and (4) control conjugate (normal sheep IgG-Dex-Dau), was less toxic and more effective in tumor growth inhibition (P<0.05).

关 键 词：肝肿瘤 癌 铁蛋白 抗体 柔红霉素 

分 类 号：R735.7[医药卫生—肿瘤]