血浆同型半胱氨酸和血清叶酸水平与胃黏膜异型增生的关系  

Relevance of Plasma Homocysteine and Serum Folic Acid Levels and Gastric Dysplasia

作　　者：沈必武[1] 王毓明[1] 庞智[1] 李明珍[1] 华江[1] 郑家驹[1] 

机构地区：[1]江苏省苏州市第三人民医院消化科

出　　处：《胃肠病学》2004年第5期294-296,共3页Chinese Journal of Gastroenterology

摘　　要：背景近年来,同型半胱氨酸与细胞癌变的关系已引起广泛重视。叶酸及其辅酶对活细胞的生长发育等功能具有重要影响,叶酸缺乏与多种肿瘤的发生有关。目的了解胃黏膜异型增生患者的血浆同型半胱氨酸和血清叶酸水平,并探讨其间的关系。方法选取29例胃黏膜异型增生患者和25名健康对照者,采用高效液相色谱法测定血浆同型半胱氨酸水平,微生物学法测定血清叶酸水平。结果胃黏膜异型增生患者的血浆同型半胱氨酸水平显著高于健康对照者(14.74μmol/L±5.40μmol/L对8.16μmol/L±3.50μmol/L,P<0.001),血清叶酸水平显著低于健康对照者(4.29ng/ml±3.13ng/ml对11.24ng/ml±4.26ng/ml,P<0.001)。结论胃黏膜异型增生与血浆同型半胱氨酸水平升高和血清叶酸水平降低之间存在一定联系。血浆同型半胱氨酸水平升高和血清叶酸水平降低可能是胃黏膜异型增生的危险因素,有必要对此作进一步的探讨。Background: The relevance of homocysteine and carcinomatous changes has been a topic of considerable interest in recent years. Folic acid and its coenzyme are necessary for the growth and development of living cells, and folic acid deficiency may promote tumorigenesis in many kinds of cells. Aims: To identify the plasma homocysteine and serum folic acid status in patients with gastric dysplasia, and to investigate their relevance. Methods: Twenty-nine patients with gastric dysplasia and 25 healthy controls were enrolled. The plasma level of homocysteine was measured by high-performance liquid chromatography, and serum level of folic acid by microbiological assay. Results: In patients with gastric dysplasia, the plasma level of homocysteine was significantly higher than that of the healthy controls (14.74 μmol/L±5.40 μmol/L vs. 8.16 μmol/L±3.50 μmol/L, P<0.001), and the serum level of folic acid was markedly lower than that of the healthy controls (4.29 ng/ml±3.13 ng/ml vs. 11.24 ng/ml±4.26 ng/ml, P<0.001). Conclusions: Gastric dysplasia may be correlated with the increased plasma homocysteine and decreased serum folic acid levels. Increased plasma homocysteine and decreased serum folic acid levels may be the risk factors for gastric dysplasia, further studies are awaited.

关 键 词：高半胱氨酸 叶酸 胃黏膜 异型增生 细胞癌变 

分 类 号：R573[医药卫生—消化系统]