洛赛克治疗胃食管反流的临床疗效  

The Clinical Effect of Losec in the Treatment of Gastroesophageal Reflux Disease

作　　者：张子昭[1] 赵进清 李树林[1] 胡汝东 

机构地区：[1]玉门油田医院消化科,甘肃省玉门市735200

出　　处：《中国全科医学》2004年第22期1648-1649,共2页Chinese General Practice

摘　　要：目的　评价洛赛克治疗胃食管反流病 (GERD)的疗效。方法　选择我院 1999～ 2 0 0 3年 6月诊断的GERD患者 80例 ,进行内镜检查并分级。将 80例患者随机分成两组 ,每组 4 0例。治疗组口服洛赛克 2 0mg,1～ 2次 /d;对照组口服雷尼替丁 15 0mg,2次 /d。 4周后复查胃镜并观察临床症状改善情况 ,判定疗效并观察药物副作用。结果　两组患者疗效间的差别有显著性意义 (P <0 0 5 ) ;两组治疗后内镜检查结果间差别有显著性意义 (P <0 0 5 )。两组不良反应发生率均为 5 0 % ,均未发现血、尿常规及肝、肾功能异常。结论　洛赛克治疗GERD疗效好 ,副作用少 ,使用方便 ,值得推广应用。Objective To evaluate the clinic effect of losec in the treatment of gastroesophageal reflux disease (GERD).Methods Eighty patients of GERD were chosen from Jan.1999 to Jun.2003 in our hospital.To observe their′s main clinical symptom,then use endoscope to check and classify.All patients were randomly divided into two groups.Group A (n=40) was treated with losec (20 mg,p.o.qd or bid) and group B (n=40) was treated with ranitidine (150 mg,p.o.bid).The two groups were counterchecked endoscope and observe clinical symptom to judge effect and observe medicines side effect after four weeks.Results Group A have 22 (55.0%) clear effect,16(40.0%) effect and the availability rate was 95.0%.Group B have 16 (40.0%) clear effect,12 (30.0%) effect and the availability rate was 70.0%.There was a significant difference in curative effect between the two groups (P<0.05).The healing rate of endoscope was a significant difference too (P<0.05).Two group′s side effect rate were 5.0% and there were no abnormal blood routine,urine routine,liver function and kidney function.Conclusion Losec has more effects than ranitidine′s,it has less side effect,used more convenient,is worth widening and applying.

关 键 词：洛赛克 治疗 胃食管反流 疗效观察 

分 类 号：R573[医药卫生—消化系统]